Trial to Evaluate the Use of Pomegranate Concentrate (POMx) for the Prevention of Experimental Rhinovirus Infection
- Conditions
- Common Cold
- Registration Number
- NCT00655031
- Lead Sponsor
- POM Wonderful LLC
- Brief Summary
Pomegranate has a long history of use in folk medicine. There is vast data on the health benefits of pomegranate fruit and juice. Multiple studies have established the strong antioxidative effects of pomegranate polyphenols (primarily the ellagitannin punicalagin) and their health effects. A vast number of animal and human clinical studies have provided evidence on effect of pomegranate products on reducing symptoms of common cold, reducing blood pressure, improving endothelial function, anti-tumor activity, and its anti-atherosclerotic activity. This study will evaluate the protective effect of a pomegranate concentrate (POMx) in decreasing the incidence and duration of the common cold among healthy adults.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
- Nonsmoker
- No recent history of respiratory disease
- Serum positive for rhinovirus
- Pregnant or breastfeeding
- Recent immunization
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method The proportion of subjects who become infected in the active treatment group compared with the proportion of subjects who become infected in the placebo treatment group. Days 1-5
- Secondary Outcome Measures
Name Time Method Comparison of symptom scores in the treatment groups Days 1-5 Determination of effects of treatment on immune function. Days 1-5
Related Research Topics
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Trial Locations
- Locations (3)
Accelovance Inc.
🇺🇸Huntsville, Alabama, United States
Accelovance Inc
🇺🇸Melbourne, Florida, United States
University of Virginia School of Medicine
🇺🇸Charlottesville, Virginia, United States
Accelovance Inc.🇺🇸Huntsville, Alabama, United States