Effect of autologous platelet-rich plasma on improving pregnancy outcomes in repeated implantation failure :A randomized controlled trial

Phase 3

Conditions: Infertility.
Complications of attempted introduction of embryo in embryo transfer
N98.3

Registration Number: IRCT2017061434525N1

Lead Sponsor: Iranian academic center for education culture and research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 118

Inclusion Criteria

Women of childbearing age (18-45 yrs)
A history of RIF (repeated implantation failure) during ART(Assisted reproductive technology ) treatments

Exclusion Criteria

pregnancy,
Diagnosed cancers,
Hemoglobin less than 11 gr per deciliter,
Patelets less than 150,000/ cc,
Use of anticoagulants,
Use of Non-steroidal anti-inflammatory drugs up to 10 days before the procedure,
Any physical or mental illness that affects the patient's immunity and admission and disrupts the process of project implementation and patient follow-up.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Positive pregnancy report with ßHCG laboratory confirmed. Timepoint: 4 weeks after intervention. Method of measurement: Measurement of ßHCG hormone (mg / dl) by the Laboratory.;Check the pregnancy sac ,. Timepoint: 3 weeks after the check of positive HCG. Method of measurement: sonography.;Check the fetus heart rate. Timepoint: 7 weeks after intervention. Method of measurement: sonography.

Secondary Outcome Measures

Name	Time	Method
Ongoing Intrauterine pregnancy diagnosis. Timepoint: During pregnancy. Method of measurement: sonography.;Ectopic pregnancy. Timepoint: During pregnancy. Method of measurement: sonography.;Abortion. Timepoint: During pregnancy. Method of measurement: sonography.;Live birth. Timepoint: end of pregnancy. Method of measurement: child birth.