Impact of Transcranial Direct Current Stimulation of the Motor Cortex on Language Functions in Residual Aphasia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Residual Aphasia
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Response latency during picture naming task (max. 80)
- Last Updated
- 13 years ago
Overview
Brief Summary
The present study assesses whether language functions in patients with residual post-stroke aphasia can be improved by transcranial direct current stimulation administered to the primary motor cortex in the language dominant (left) hemisphere.
Detailed Description
Patients will participate in two tDCS sessions (atDCS; sham) in a cross-over within subjects design. tDCS or placebo will be administered during simulatneous fMRI to assess neural signatures of the stimulation. Order of stimulation will be counterbalanced between subjects
Investigators
Marcus Meinzer
Creutzfeldt Fellow
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •right handedness
- •German native speaker
- •cerebrovascular stroke in left hemisphere (\>6 months)
- •mild aphasia (according to Aachen Aphasia Test Battery Classification, Huber et al., 1983)
- •residual anomia in naming test (\>75 correct responses)
Exclusion Criteria
- •other current or previous neurological or psychiatric diseases
- •alcohol or drug abuse
- •MRI contraindication (e.g. magnetic metal, pacemaker, claustrophobia)
Outcomes
Primary Outcomes
Response latency during picture naming task (max. 80)
Time Frame: Change in response latency between assessment 1 (week 1) and assessment 2 (week 2), assessments 1 and 2 are seperated by one week
Subjects are assessed in a cross-over design. The primary outcome measure will be assessed twice in each subject, either during placebo ("sham) stimulation or active (anodal) stimulation with transcranial direct current stimulation. Order of stimulation will be counterbalanced across the group.
Secondary Outcomes
- Change in neural activity measured by functional magnetic resonance imaging(Change in fMRI activity between Assessment 1 (week 1) and Assessment 2 (week 2), assessments 1 and 2 are seperated by one week)