Screening Cardiovascular Patients for Aortic aNeurysms (SCAN)

• Conditions: Abdominal Aortic Aneurysm; AAA

• Registration Number: NCT02179801
• Lead Sponsor: Technical University of Munich

Brief Summary

The aim of the cohort study SCAN (Screening Cardiovascular patients for Aortic aNeurysms) is to establish a screening programm for patients with a high risk for an AAA. Aortic aneurysms in these patients should be identified at an early stage and thereby AAA-associated mortality be decreased.

Detailed Description

A recently published meta-analysis showed a higher prevalence of aortic aneurysm (AAA) in men requiring treatment of coronary heart disaese compared to standard population. In women, however, the prevalence was not increased. Thus, the SCAN project addresses male patients who underwent coronary artery intervention in order to screen them for the presence of an AAA using duplex sonography.

The SCAN project involves the following elements:

1. Informing the patient with cardiovascular risk factors about the clinical picture of AAA

2. An ultrasound scan of the abdominal aorta in patients with an increased risk for AAA

3. Acquisition of patient data followed by a correlation analysis for the parameters presence of AAA and cardiovascular diseases

The cohort study is part of the SCAN project which is also conducted in an similar way by Catharina Ziekenhuis Eindhoven ClinicalTrials.gov Identifier:NCT01643317.

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-06-12
• Study First Submitted QC: 2014-06-30
• Study First Posted: 2014-07-02
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-05
• Last Update Posted: 2017-01-06
• Primary Completion: 2017-12
• Study Completion: 2018-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 1000

Inclusion Criteria

• men with coronary artery intervention (PTCA/stenting)
• at least 1 risk factor for AAA (hypertension, hyperlipidaemia, hyperuricemia, nicotine abuse,positive family history)

Exclusion Criteria

• life expectancy less than 1 year
• inability to follow the instructions of the investigator (dementia, lack of time, insufficient understanding of the language)
• insufficient compliance

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of AAA	1 year	Ultrasound screen for the presence of an AAA

Secondary Outcome Measures

Name	Time	Method
Correlation of the number of treated vessels and AAA	1 year
Correlation of risk factors for AAA with risk factors for coronary artery disease	1 year	Therefore the cardiovascular risk factors ( diabetes, hypertension, hyperlipidaemia, hyperuricemia, nicotine abuse, positive family history, obesity) will be requested.
Prevalence of AAA in the cohort requiring treatment	1 year	Measuring the AAA diameter
Distribution of risk factors	1 year	Distribution of cardiovascular risk factors (diabetes, hypertension, hyperlipidaemia, hyperuricemia, nicotine abuse, positive family history, obesity) between patients with an without an AAA

Trial Locations

Locations (2)

Klinikum rechts der Isar, Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie; 🇩🇪 Munich, Bayern, Germany

I. Medizinischen Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München; 🇩🇪 München, Bayern, Germany