Is the lower incidence of intradialytic hypotension during Hemocontrol dialysis in comparison with standard hemodialysis attributable to enhanced to higher plasma vasopressin levels or to enhanced sympathetic activity and/or to less nitric oxide production?

Completed

• Conditions: Vasopressine, sympathicusactiviteit, stikstofoxideproductie en dialyse hypotensie; Dialysis hypotension; 10038430

• Registration Number: NL-OMON37739
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-03-25
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Hypotension-prone dialysis patients including patients who have stable hemodialysis session on Hemocontrol but previously had dialysis hypotension on standard hemodialysis

Exclusion Criteria

Patients on hemodialysis duration < 4 hours or > 4 hours

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome<br /><br>Plasma vasopressin levels</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes<br /><br>Sympathetic activity (primarily defined as the low frequency band in<br /><br>measurements of heart rate variability, secondarily defined as plasma<br /><br>noradrenalin levels) and nitric oxide metabolites as a parameter of endogenous<br /><br>nitric oxide production of vascular endothelial cells. In addition, plasma<br /><br>sodium levels, plasma osmolality, baroreflex sensitivity, peripheral vascular<br /><br>resistance and the course of the relative blood volume, blood pressure and<br /><br>heart rate. </p><br>