Comparison of the effect of two different types of drugs when mixed to the local anaesthetics for upper limb block

Phase 3

Not yet recruiting

• Conditions: Diseases of the musculoskeletal system and connective tissue,

• Registration Number: CTRI/2020/05/025082
• Lead Sponsor: Jyoti Mala

Brief Summary

Supraclavicular brachial plexus blockade  is the common approach to provide surgical anesthesia of upper limb, was first described by Kulenkampff in 1911.(1) It is an efficient regional anesthetic technique for upper limb surgeries. Which is a reliable, alternative to general anesthesia for certain group of patients as it is devoid of undesired effects of general anesthesia and stress of laryngoscopy. The postoperative period is also free from pain, nausea, vomiting, and respiratory depression. Adjuvants are added to local anaesthetics to improve various block characteristics in terms of onset of action ,duration of analgesia with lesser adverse effect. Various study has been done using different types of adjuvants in different combination of local anaesthetics for various nerve blocks. In our study we will use levobupivacaine LA because it is relatively safe in terms of less cardiac and neurotoxic adverse effects. Dexmedetomidine is a highly selective an alpha 2 agonist which, when used as an adjuvant , prolongs the duration of action  without causing respiratory depression. Nalbuphine is recently introduced opioid agonist-antagonist. Unlike other opioids it has got ceiling effect. Furthermore,use  of ultrasound (US) has significantly improved the quality of nerve blocks by direct visualization of nerves and related anatomical structures, needle trajectory and spread of local anesthetics (LAs) during injection [2-7]. In addition, US guidance increases success rate, minimizes LAs volume needed for effective nerve block, and avoids potential complications such as intraneural or intravascular injection [2,4,5]. In this study, we plan to compare the efficacy of dexmedetomidine and nalbuphine as an adjuvant to levobupivacaine in ultrasound guided supraclavicular brachial plexus block.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-06-05
• Study Start: 2020-11-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Patients posted for upper limb surgery of either side 2.
• Patients of ASA physical status 1 & 2 3.
• Patients between 18-50 years of age of either sex 4.
• Patients able to comprehend and willing to participate.

Exclusion Criteria

• Patient’s refusal to participate 2.
• Patients of ASA physical status3 & 4 3.
• Any allergy to local anaesthetics 4.
• Coagulation disorders 5.
• Infection at the site of intervention 6.
• History of any underlying cardiac, renal or hepatic dysfunction •Pregnant patient.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Onset of motor block	3 months
2. Onset of sensory block	3 months
3. Duration of analgesia	3 months

Secondary Outcome Measures

Name	Time	Method
1. Hemodynamic stability	2. Side effects

Trial Locations

Locations (1)

Indira Gandhi Institute of Medical Sciences; 🇮🇳 Patna, BIHAR, India

Indira Gandhi Institute of Medical Sciences

🇮🇳Patna, BIHAR, India

Dr Arvind Kumar

Principal investigator

9534870908

arvind007kumar@yahoo.com