Impairments and complaints during activities of daily living in patients with mild COPD.

Completed

Conditions: chronic airflow limitation
chronic obstructive pulmonary disease (COPD)
10038716

Registration Number: NL-OMON35698

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 125

Inclusion Criteria

Patients: Clinically stable COPD patients with GOLD stage I (= mild COPD, a FEV1/VC ratio (forced expiratory volume in one second divided by the vital capacity) < 0.7 and FEV1 >= 80% of predicted) and >=18 years old.
Controls: Subjects with normal lung function and with similar ages and gender distribution as the patients with COPD.

Exclusion Criteria

Patients: patients with long term oxygen therapy at home, with co-existing lung disease other than COPD (including asthma), with restrictive lung function, with other exercise-limiting disorders than COPD like cardiac or neuromuscular disease, or patients using β-blockers are excluded from the study.
Controls: subjects with abnormal lung function or history of lung disease, with exercise-limiting disorders like cardiac or neuromuscular disease, or using β-blockers are excluded from the study.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>For the first objective, the main study parameter is dynamic hyperinflation<br /><br>during ADL in patients with mild COPD and in controls. For the second<br /><br>objective, the main study parameter is the difference in dynamic hyperinflation<br /><br>during ADL in patients and controls after a two-year interval.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>During ADL:<br /><br>Ventilatory parameters: ventilation (Ve), breathing reserve (BR), Ve/maximal<br /><br>ventilatory capacity (MVC), ventilatory equivalent for CO2 (Ve/VCO2), partial<br /><br>pressure of end-tidal CO2 (PetCO2), breathing frequency (BF).<br /><br>Operational lung volumes: inspiratory reserve volume (IRV), tidal volume (Vt)<br /><br>Cardiovascular parameters: heart rate (HR), HR reserve, O2-pulse, blood<br /><br>pressure<br /><br>Other: oxygen consumption (VO2), dyspnea, ADL-time, gas exchange</p><br>