Impact of Blood Flow Restriction on Hematological Factors in Anemic Young Females
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- haemoglobin concentration
研究概览
简要总结
Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this issue.
详细描述
Anemia is a global public health problem affecting both developing and developed countries at all ages, with major consequences for human health as well as social and economic burden. Iron deficiency affects more than 2 billion people world wide, and iron deficiency anemia (IDA) remains to be the top cause of anemia.
For decades, blood flow restriction (BFR), originating from Japan, has become one of the most popular techniques in physiotherapy. To perform the BFR technique, a controlled tourniquet is performed, generating a gradual mechanical pressure just below it, affecting blood flow (both arterial and venous) and generating a hypoxia in the restricted area. For the realization of the tourniquet, mechanical cuffs are used, which are inflated and regulate the pressure generated in the compression zone, although nylon or elastic cuffs are also used for the realization of the tourniquet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 25 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hb more than 8 and less than 12 in females.
- •Age: 19-25 year.
- •BMI ranging from 25 to 29.9 kg/m
- •No existing inflammatory conditions including rheumatoid arthritis disorders of the lower extremities.
- •Physical activity level less than 150 min per week
排除标准
- •unstable hypertension, venous thromboembolism, hypercoagulable states, varicose veins, pregnancy, and hemophilia.
- •inherited or acquired red cell disorders (haemoglobinopathies).
- •acute or chronic infections (malaria, tuberculosis, HIV),.
- •severe anemia (Hb <8 g/dL).
- •History of cardiovascular diseases.
- •Nutritional anemia (B12/folate)
- •Peripheral arterial disease.
- •Intermittent claudication.
- •Non smokers
研究组 & 干预措施
Aerobic Exercise + Blood Flow Restriction
25 female will receive blood flow restriction with low intensity aerobic exercise participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group.
干预措施: aerobic exercise + blood flow restriction (Device)
Aerobic Exercise
25 subject participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down.
干预措施: aerobic exercise (Procedure)
结局指标
主要结局
haemoglobin concentration
时间窗: Baseline and 12 weeks
Serum ferritin level
时间窗: Baseline and at 12 weeks
Haematocrit
时间窗: Baseline and at 12 weeks
Red blood cell (RBC) count
时间窗: baseline and at 12 week
Mean corpuscular volume (MCV)
时间窗: baseline and at 12 week
Mean corpuscular haemoglobin (MCH)
时间窗: baseline and at 12 week
次要结局
- Quality of life assessed using the SF-36 questionnaire(baseline and at 12 week)
- Estimated maximal oxygen consumption (VO₂max) derived from the ISWT(baseline and at 12 week)
- Functional capacity assessed using the Incremental Shuttle Walk Test (ISWT)(baseline and at 12 week)
研究者
noha sameh
assistant lecturer
Cairo University