NL-OMON38535
Completed
Not Applicable
Gene expression analysis elucidating pathogenic mechanisms and predicting vespid venom anaphylaxis - GEIVA
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Vespid venom allergy
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 20
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\* A clear positive history of a systemic response grade II, III or IVa after a vespid sting
- •\* Vespid specific serum IgE \> 0\.35 kUA/l or a positive intracutaneous skin test for vespid venom (at \<\= 1 µg/ml a histamine equivalent prick of \>\=0\.7\)
- •written informed consent
Exclusion Criteria
- •\* A positive history of a systemic response grade IVb according to Mueller (13\) after a vespid sting
- •\* Age under 18 years or above 65 years
- •\* Incapacitated subjects
- •\* Severe cardiopulmonary disease (clinical evidence of congestive heart failure, coronary disease or severe hypertension)
- •\* Insufficiently controlled asthma based on history, asthma control questionnaire and if the observed FEV1 is 70% of predicted.
- •\* Conditions that influence the immune system (immune deficiencies, malignancy, auto\-immune diseases, flulike dissease)
- •\* Severe kidney failure
- •\* Interfering medication with the outcome or recovery from a systemic reaction (β\-blockers and immunosuppressive drugs)
- •\* Pregnancy(measured before inclusion by β\-hCG)
- •\* Mastocytosis
Outcomes
Primary Outcomes
Not specified
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