Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Other: Exercise

• Registration Number: NCT03856801
• Lead Sponsor: Universidad Católica San Antonio de Murcia

Brief Summary

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

Detailed Description

* Crossover.

* 13 patients with multiple sclerosis were recruited.

* Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Study Timeline

• Study Start: 2018-06-15
• Primary Completion: 2018-07-30
• Study Completion: 2018-08-30
• Status Verified: 2019-02
• Study First Submitted: 2019-02-13
• Study First Submitted QC: 2019-02-25
• Last Update Submitted: 2019-02-25
• Study First Posted: 2019-02-27
• Last Update Posted: 2019-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• mild or moderate disability with clinical mild spastic-ataxic gait disorder.
• stable phase of the disease.

Exclusion Criteria

• Expanded Disability Status Scale (EDSS) < 6.
• relapsing disease within the preceding 12 months.
• corticosteroid treatment within the last months before study inclusion.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Whole-body vibration in hypoxia condition	Exercise	Training session in hypoxia condition
Whole-body vibration in normoxia condition	Exercise	Training session in normoxia condition

Primary Outcome Measures

Name	Time	Method
Rate of Force Development	Immediately after the training sessions
Central Activation Ratio	Immediately after the training sessions
Maximal Voluntary Isometric Contraction of Knee Extension	Immediately after the training sessions
Biomechanical study of the walk by video recording	Immediately after the training sessions	Stride amplitude during walking
Spasticity	Immediately after the training sessions	Pendulum test

Secondary Outcome Measures

Name	Time	Method
Rate of Perceived Exertion	Immediately after the training sessions	RPE Scale 6-20
Walking speed	Immediately after the training sessions	Test 10 m-walks
Static balance	Immediately after the training sessions	Romberg Test with eyes open and closed. Analysis with force plates
Muscle oxygenation in soleus	Immediately after the training sessions	MOXY's

Trial Locations

Locations (1)

Universidad Católica San Antonio; 🇪🇸 Murcia, Spain