Refining Cough Skill Training in Parkinson's Disease and Dysphagia

Phase 1

Completed

• Conditions: Parkinson Disease; Dysphagia
• Interventions: Behavioral: Cough Skill Training - with Variable Practice

• Registration Number: NCT05700838
• Lead Sponsor: Teachers College, Columbia University

Brief Summary

Airway protection deficits (cough and swallowing) are prevalent and pervasive in Parkinson's disease (PD), contributing to adverse health outcomes like pneumonia. This study aims to refine cough skill training by examining whether variable versus constant practice conditions improve cough outcomes in people with PD. In addition, this study will provide insight into optimal respiratory adaptations that occur during training to support cough effectiveness, resulting in immediately translatable treatments to improve airway protection-related health outcomes in people with neurodegenerative disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-21
• Study First Submitted: 2022-12-21
• Study First Submitted QC: 2023-01-17
• Study First Posted: 2023-01-26
• Primary Completion: 2023-06-28
• Study Completion: 2023-06-28
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-09
• Last Update Posted: 2024-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cough Skill Training	Cough Skill Training - with Variable Practice	During cough skill training, participants will be seated in front of a computer with real-time visualization of their cough waveform. A target line will be provided, and participants will be instructed to perform a single voluntary cough so that their peak flow is within the target's range. Participants will be instructed to continue the cough training regardless of initial accuracy.

Primary Outcome Measures

Name	Time	Method
Change in Peak Expiratory Flow Rate	Before to after two sessions of cough variable practice training over two weeks	Cough Strength

Secondary Outcome Measures

Name	Time	Method
Change in Respiratory Kinematics, specifically lung volume excursion	Before to after two sessions of cough variable practice training over two weeks

Trial Locations

Locations (1)

Teachers College, Columbia University; 🇺🇸 New York, New York, United States