Assesment of antioxidant status in vivo and in vitro of guarana (Paullinia cupana).
Not Applicable
- Conditions
- Plasma and LDL susceptibility to oxidationAntioxidant acitivity of the Enzymes Superoxide Dismutase, Catalase and Glutathione Peroxidase.Diet and Nutrition - Other diet and nutrition disorders
- Registration Number
- ACTRN12609000758202
- Lead Sponsor
- Carolina de Aguiar Martins
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Body Mass Index (BMI).: 24.90 kg/m2 < BMI> 29.90 Kg/m2 (overweight)
tryglicerides: < 400mg/dl
total cholesterol: <200 mg/dl
LDl cholesterol: from 100 to 159 mg/d
Exclusion Criteria
Vegetarian diet, pregnant , smoking, obesity, diabetes, hypertension,chronic heart disease (CHD) history, hepatic desease, regular use of supplements or drugs, sensibility to caffeine or any other chronic desease.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We will evaluated plasma total antioxidant status (TAS), the kinetics of diene conjugate generation, and thiobarbituric acid reactive substance (TBARS) contents in plasma, as well as antioxidant activity of gluthatione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT).[A baseline blood sample will be collected on a twelve-hour overnight fast (T=1) and after one hour guarana consumption the second blood sample will be collected (T=2). 15 days after drinking the beverage, another blood sample will be collected one on a twelve-hour overnight fast (T=3) and other after one hour of drinking the beverage (T=4).]
- Secondary Outcome Measures
Name Time Method Commet Assay in lymphocytes.[A baseline blood sample will be collected on a twelve-hour overnight fast and 15 days after drinking the beverage, another blood sample will be collected one on a twelve-hour overnight fast.]