Beverage prepared with grape by-product: effect on oxidative stress and coronary artery disease markers in human beings

Not Applicable

• Conditions: Plasma and LDL susceptibility to oxidation; Antioxidant activity of the enzymes Superoxide Dismutase, Catalase and Glutathione Peroxidase; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12609000824268
• Lead Sponsor: Marcela Piedade Monteiro

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-09-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Body Mass Index (BMI): great than 19 kg/m2 and less than30 kg/m2,

Exclusion Criteria

Pregnant, vegetarian diet, smoking, obesity, hypertension, use of supplements or drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We will evaluated plasma total antioxidant status (TAS), the kinetics of diene conjugate generation and thiobarbituric acid reactive substance (TBARS) contents in LDL , as well as antioxidant activity of gluthatione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT).[Blood samples of the individuals will be collected at baseline, after two weeks of intervention and the same protocol will be performed after fourteen days of washout];Triacylglycerols, total cholesterol and its fractions, C-reactive protein, Interleukin-6 and tumor necrosis factor alpha (TNF-alpha) will be evaluated at the beginning and end of the experiment.[Blood samples of the individuals will be collected at baseline, after two weeks of intervention and the same protocol will be performed after fourteen days of washout]

Secondary Outcome Measures

Name	Time	Method
Deoxyribonucleic acid (DNA) damage will be analyzed in blood lymphocytes using the Comet Assay.[Blood samples of the individuals will be collected at baseline, after two weeks of intervention and the same protocol will be performed after fourteen days of washout]