CTRI/2023/05/052687招募中3 期
POLYMYXIN vs. CEFTAZIDIME-AVIBACTAM with AZTREONAM for primary treatment of Carbapenem Resistant Enterobacteriaceae (CRE) and Carbapenem Resistant Pseudomonas aeruginosa (CRPA) - CARE
AIIMS, Newdelhi0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •2.Sepsis (as per Sepsis-3 definition)
- •3.CRE/PA detected on blood culture (Bact T Alert), followed by Malditof ID
- •4.Carbapenemase gene positive PCR assay.
排除标准
- •1.Refusal of consent
- •2.Colistin resistance gene positive on PCR assay
- •3.Patient not expected to survive more than 4 days (decided clinically)
- •4.Patients on significant vasopressor support at the time of enrolment (defined as noradrenaline requirement more than 0.1 mcg/kg/min)
- •5.Patient allergic to either of the drugs in the control or intervention group
- •6.Patient with significant polymicrobial infection [coinfection with two different CRE, or CRE and CRPA, or CRE/CRPA and Acinetobacter Baumannii/gram positive bacteria (Gram positive skin contaminant in one set of blood cultures is not regarded as significant polymicrobial bacteraemia)].
- •7.Pregnancy or breast feeding
- •8.Significant pre-existing comorbidities – CKD 4/5, CLD
- •9.Patients already receiving either CAZ-AVI/ATM or polymyxins prior to enrolment
研究者
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