Lymphatic Function During Mechanical Ventilation
- Conditions
- Lymphatic Insufficiency
- Registration Number
- NCT05770752
- Lead Sponsor
- Rigshospitalet, Denmark
- Brief Summary
This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation.
The lymphatic function will be examined using Near-Infrared Fluorescence Imaging.
- Detailed Description
This study wil examine the effect of altered intrathoracic pressure on lymphatic function. This will be done by investigating peripheral lymphatic vessels on patients undergoing surgery for malformations of the jaw who are being mechanically ventilated.
Subjects will be examined on two occasions. One to establish baseline function, and one during surgery following a ventilation protocol with altered PIP and PEEP.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Patients undergoing surgery for jaw malformations
- Age > 18 years
- Informed consent
- Cardiopulmonary healthy
- History of Cardiac disease
- History of pulmonary disease
- History of lymphatic disease
- Peripheral edema
- Chronic infectious disease
- Age > 30 years
- BMI > 30
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Peripheral lymphatic frequency (contractions/minute) 3 hours Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences.
Peripheral lymphatic velocity (centimeters/second) 3 hours Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Copenhagen University Hospital
🇩🇰Copenhagen, Denmark