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Clinical Trials/ISRCTN24953404
ISRCTN24953404
Completed
Not Applicable

Memantine for AGitation in Dementia

East Kent Hospitals Research and Development Committee (UK)0 sites164 target enrollmentOctober 3, 2006
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ConditionsAlzheimers DiseaseNervous System Diseases

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Alzheimers Disease
Sponsor
East Kent Hospitals Research and Development Committee (UK)
Enrollment
164
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
October 3, 2006
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
East Kent Hospitals Research and Development Committee (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Residential/inpatients
  • •2\. Alzheimers\-McKhann Criteria and Haschinski less than four
  • •3\. Mini\-Mental State Examination (MMSE) score less than or equal to 19
  • •4\. Clinically significant agitation requiring treatment
  • •5\. Cohen\-Mansfield Agitation Inventory (CMAI) score more than or equal to 45
  • •6\. Aged 55 years or more

Exclusion Criteria

  • •1\. Memantine use in four weeks prior
  • •2\. On cholinesterase inhibitors for less than three months and dose not stable
  • •3\. Anti\-psychotic, antibiotic, anti\-epileptic, anti\-depressant, benzodiazepine, lithium, or hypnotic dose alteration in two weeks prior to start
  • •4\. Antiparkinsonsian medication
  • •5\. Hypersensitivity to memantine or components
  • •6\. Severe renal impairment
  • •7\. Epilepsy, history of convulsions or seizure, or receiving anti\-epileptics
  • •8\. Concomitant usage of N\-Methyl\-D\-Aspartic acid (NMDA) antagonists amantadine, ketamine, dextromethorphan
  • •9\. Recent Myocardial Infarction (MI), uncompensated Congestive Cardiac Failure (CCF) and uncontrolled hypertension
  • •10\. Severe, unstable or poorly controlled medical illness

Outcomes

Primary Outcomes

Not specified

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