ISRCTN24953404已完成不适用
Memantine for AGitation in Dementia
East Kent Hospitals Research and Development Committee (UK)0 个研究点目标入组 164 人开始时间: 2006年10月3日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 164
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Residential/inpatients
- •2. Alzheimers-McKhann Criteria and Haschinski less than four
- •3. Mini-Mental State Examination (MMSE) score less than or equal to 19
- •4. Clinically significant agitation requiring treatment
- •5. Cohen-Mansfield Agitation Inventory (CMAI) score more than or equal to 45
- •6. Aged 55 years or more
排除标准
- •1. Memantine use in four weeks prior
- •2. On cholinesterase inhibitors for less than three months and dose not stable
- •3. Anti-psychotic, antibiotic, anti-epileptic, anti-depressant, benzodiazepine, lithium, or hypnotic dose alteration in two weeks prior to start
- •4. Antiparkinsonsian medication
- •5. Hypersensitivity to memantine or components
- •6. Severe renal impairment
- •7. Epilepsy, history of convulsions or seizure, or receiving anti-epileptics
- •8. Concomitant usage of N-Methyl-D-Aspartic acid (NMDA) antagonists amantadine, ketamine, dextromethorphan
- •9. Recent Myocardial Infarction (MI), uncompensated Congestive Cardiac Failure (CCF) and uncontrolled hypertension
- •10. Severe, unstable or poorly controlled medical illness
- •11. Disability which affects ability to complete study
- •12. Active malignancy
- •13. Delirium, pain or medical illness as a cause of agitation
- •14. Any important drug interactions prohibited during study and in 14 days prior: analgesic (dextromethorpan), dopaminergics (amantadine, warfarin)
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