letrozole combined with gonadotropin in infertile patients with diminished ovarian reserve

Phase 4

• Conditions: infertility.; Female infertility associated with anovulation; N97.0

• Registration Number: IRCT20140224016705N9
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 72

Inclusion Criteria

women with poor ovarian response that at least two of the following three features(Bologna criteria) must be present: (i) advanced maternal age or any other risk factor for POR; (ii) a previousPOR; and (iii) an abnormal ovarian reserve test.
age 18-42 years
previous poor ovarian response(oocyte<3) to ovarian stimulation by gonadotropin.

Exclusion Criteria

metabolic disease (diabetes, chronic hypertension, etc) or any underlying disease ( kidney disease, liver disease, etc.)
presence cancer or any malignancy
genitourinary anomalies

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of oocytes achieved after letrozole+gonadotropine regimen. Timepoint: after ovarian puncture. Method of measurement: reporting by embryology laboratory.;Mean endometrial thickening after letrozole+gonadotropin regimen. Timepoint: at injection day of HCG. Method of measurement: ultrasound sonography.;Rate of pregnancy after letrozole+gonadotropin regimen. Timepoint: 2weeks after ovarian puncture. Method of measurement: level of beta human chorionic gonadotropin in a sample of blood.