Treatment Outcomes and Dosimetric Analysis Comparison Between CyberKnife and VMAT Based Methods of Stereotactic Radiotherapy for Sinonasal Malignancy
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Overall Survival, OS
研究概览
简要总结
Sinonasal Tumors are a rare type of head and neck tumor, accounting for approximately 3% of head and neck cancers. Treatment primarily involves surgical intervention, with radiation therapy as an adjunct. Due to the tumor's anatomical location near critical structures such as the eyes, optic nerves, optic chiasm, brainstem, and oral cavity, if the tumor cannot be completely resected, postoperative radiation therapy is often necessary. Given the complexity of the tumor's anatomical position, subsequent radiation therapy planning becomes more challenging, as it must balance tumor control and organ preservation. This study retrospectively analyzes patients with sinonasal tumors who received stereotactic radiosurgery (CyberKnife) at our hospital, comparing the dosimetric advantages, treatment efficacy, survival analysis, and side effects with those of volumetric modulated arc therapy (VMAT).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The pathological tissue report from the endoscopic surgery at this hospital confirmed a diagnosis of malignant sinus tumor.
- •Received radical stereotactic radiotherapy at this hospital.
- •Pre-treatment baseline imaging (CT or MRI) was performed.
- •Received radical radiotherapy at this hospital and has been under long-term follow-up with complete medical records at this hospital.
排除标准
- •Local lymphatic metastasis and distant metastasis have been excluded by imaging examinations (cN >=1, M =1).
- •Not treated with radical radiotherapy at this hospital and has been under long-term follow-up at this hospital with incomplete medical records.
结局指标
主要结局
Overall Survival, OS
时间窗: Data within five years after treatment.
Determine the start dates of surgery and radiotherapy from the hospital\'s medical record system, and collect data on death events, regardless of whether they are tumor-related.
Disease-Free Survival, DFS
时间窗: Data within five years after treatment
Determine the treatment start date from the hospital\'s medical record system, and confirm whether there is any disease recurrence or progression through follow-up data or imaging examination results.
Local Control, LC
时间窗: The observation periods are 1 year, 3 years, and 5 years after treatment.
Measure the proportion of no recurrence in the local tumor area after treatment. Researchers determine the treatment start date from the hospital\'s medical record system and confirm the presence or absence of local tumor recurrence through follow-up data, imaging examinations, and pathology results.
Distant Metastasis-Free Survival, DMFS
时间窗: The observation periods are 1 year, 3 years,and 5 years after treatment.
Measure the time until the occurrence of distant metastasis after treatment. Researchers first determine the treatment start date, and then assess distant metastasis through data, imaging examinations, and clinical evaluations.
次要结局
- treatment-related side effects(complications related to treatment within 30 days)
- Dosimetric Outcomes(Data for five years after treatment.)