Common Genetic Variation and Type 2 Diabetes
- Conditions
- Pre-diabetes
- Interventions
- Other: Oral glucose tolerance test
- Registration Number
- NCT00707616
- Lead Sponsor
- Mayo Clinic
- Brief Summary
Type 2 diabetes is a common metabolic disorder arising from a complex interaction between genetic predisposition and the environment. The development of this disorder is preceded by impaired glucose tolerance and elevated fasting glucose which also carry adverse cardiovascular risk. To date a few common genetic variants have been reliably associated with predisposition to type 2 diabetes. However, it is uncertain how these genes interact to alter insulin secretion and insulin action prior to the development of type 2 diabetes. We propose to utilize an established population-based cohort to determine how common genetic variants associated with type 2 diabetes alter the response to an oral glucose challenge in people without overt type 2 diabetes. This will enable us to understand how common variants alone or in combination alter whole-body glucose physiology and predispose to type 2 diabetes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 190
- Fasting blood glucose < 126mg/dL
- Fasting blood glucose > 126mg/dL
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description A Oral glucose tolerance test Subjects without type 2 diabetes living in Olmsted County, MN
- Primary Outcome Measures
Name Time Method Disposition Index 2 hr Measured by 7-sample, 2Hr OGTT
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mayo Clinic
🇺🇸Rochester, Minnesota, United States