Radial Artery Function Following Trans-radial Cardiac Catheterisation

Completed

• Conditions: Atherosclerosis
• Interventions: Procedure: Coronary angiography

• Registration Number: NCT02147119
• Lead Sponsor: University of Edinburgh

Brief Summary

The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography. The participants will also have radial endothelial function assessed using flow-mediated dilatation at baseline, 24 hours, one week, one month and three months post- angiography. Blood will be taken pre and 24 hours post angiography for characterisation of endothelial progenitor cell numbers and function. The hypothesis is that trans-radial catheterisation will cause a reduction in flow-mediated dilatation which peaks at 24 hours and recovers at three months. The investigators hope to correlate the rate of this recovery with peri-procedural progenitor cell numbers.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-04-07
• Study First Submitted QC: 2014-05-23
• Study First Posted: 2014-05-26
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-06
• Last Update Posted: 2017-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• Stable outpatient population aged between 18-85 attending for trans-radial cardiac catheterisation

Exclusion Criteria

• Recent myocardial infarction (<3 months)
• Severe aortic stenosis
• Chronic renal failure (eGFR<30)
• Inability to give informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients post- cardiac catheterisation	Coronary angiography	-

Primary Outcome Measures

Name	Time	Method
Change in Flow-mediated dilatation	baseline, 24 hours, one week, four weeks and three months post-angiography	Radial artery flow-mediated dilatation will be assessed at the above stated time points

Secondary Outcome Measures

Name	Time	Method
Radial artery injury	Baseline and up to 1 hour Post angiograpy sheath insertion	Optical coherence tomography examination of the radial artery will be made at baseline and following sheath insertion.
Endothelial progenitor cell number an function Endothelial progenitor cell number and function	Baseline and at 24 hours post-angiogram

Trial Locations

Locations (1)

Clinical research facility University Royal Infirmary of Edinburgh; 🇬🇧 Edinburgh, Midlothian, United Kingdom