Relationship Between a Combined Index of Diastolic and Systolic Performance and Intraoperative Hemodynamic Changes During Off-pump Coronary Bypass Surgery

Completed

• Conditions: Coronary Artery Obstructive Disease

• Registration Number: NCT02534103
• Lead Sponsor: Yonsei University

Brief Summary

As considering the close relationship between systolic dysfunction and diastolic dysfunction, the EAS index e'/(a' x s') including systolic and diastolic function could be expected to predict hemodynamic changes during off-pump coronary artery bypass surgery(OPCAB). Exposure of the grafting site during OPCAB needs displacement of the heart, resulting in hemodynamic instability.

Therefore the investigators are going to evaluate EAS index with preoperative Transthoracic echocardiography(TTE) and want to know the relationship between preoperative EAS index and intraoperative hemodynamic changes in patients undergoing OPCAB, in a prospective observational study.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-07-23
• Study Start: 2015-08-04
• Study First Submitted QC: 2015-08-24
• Study First Posted: 2015-08-27
• Primary Completion: 2017-06-09
• Study Completion: 2017-06-09
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-05
• Last Update Posted: 2020-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Age ≥ 20
2. Patients undergoing multivessel off-pump coronary artery bypass surgery

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Exclusion Criteria

1. Age < 20
2. Patients with valvular heart disease
3. Congestive heart failure, NYHA class ≥III
4. Emergency surgery
5. Patients with arrhythmia
6. ST segment elevation myocardial infarction

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
sequential changes of SvO2	during OPCAB surgery	Mixed venous oxygen saturation(SvO2) reflects the balance of oxygen supply and demand immediately. Cardiac index(CI) also is a useful marker of how well the heart is functioning. Both variables can show the hemodynamic instability. With the comparison of EAS index and variables including SvO2 and CI, Investigator may draw the predictable value of the EAS index for predicting hemodynamic instability during OPCAB.
sequential changes of CI	during OPCAB surgery

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of