Understanding Pain Perception in Osteoarthritis

• Conditions: Osteoarthritis; Pain
• Interventions: Procedure: Joint replacement surgery

• Registration Number: NCT02603939
• Lead Sponsor: St George's, University of London

Brief Summary

Osteoarthritis (OA)is a painful and disabling disease, predicted to be the fourth largest cause of disability worldwide by 2020. It commonly affects the hip or knee ultimately resulting in total joint replacement. In order to assess disease progression and plan surgery, x-rays are taken as part of routine practice. However x-rays provide limited information about formation of substructures and changes occurring during progression of disease. The proposed study aims to invite patients with OA of the hip or knee to participate in detailed examinations of their pain and their painful joint through interviews, blood and urine samples taken, MRI magnetic resonance imaging)and donating their waste tissue after joint surgery (all of old joint). Informed patient consent will be sought in all cases.

Detailed Description

The patient will be asked for permission for a clinician to access their notes for information relevant to the research, including full medical history, their sex and date of birth. Tissue obtained from joint replacement surgery at St. George's Hospital and transferred to St.George's, University of London where it will be prepared for various experiments including looking at the genes and proteins in people with osteoarthritis. The blood and urine samples will also be taken to St. George's, University of London, and prepared for studies on the genes and proteins in people with osteoarthritis. All samples provided will be anonymised with no patient details on the samples and stored in locked freezers, in locked labs. at St.George's, University of London.

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2015-11-10
• Study First Submitted QC: 2015-11-11
• Study First Posted: 2015-11-13
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-23
• Last Update Posted: 2020-10-26
• Primary Completion: 2021-12
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Participants with Advanced Knee OA	Joint replacement surgery	People with advanced knee osteoarthritis requiring joint replacement surgery are being assessed for their pain responses before and after joint replacement surgery

Primary Outcome Measures

Name	Time	Method
Pain outcomes measured by Western Ontario and McMaster Universities Index (WOMAC)	1 Year after joint replacement	Western Ontario and McMaster Universities Index (WOMAC)

Secondary Outcome Measures

Name	Time	Method
Magnetic Resonance Imaging Knee Osteoarthritis Score	Pre-operatively	Level of tissue damage quantified by MOAKS scoring at baseline before joint surgery

Trial Locations

Locations (1)

Hotung Centre for Musculoskeletal Diseases; 🇬🇧 London, United Kingdom