Irinotecan and Flavopiridol in Treating Patients With Advanced Liver Cancer
- Conditions
- Liver Cancer
- Registration Number
- NCT00087282
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Brief Summary
RATIONALE: Drugs used in chemotherapy, such as irinotecan and flavopiridol, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving irinotecan together with flavopiridol works in treating patients with advanced liver cancer.
- Detailed Description
OBJECTIVES:
Primary
* Determine the time to progression in patients with advanced hepatocellular carcinoma treated with irinotecan and flavopiridol.
Secondary
* Determine the response rate and overall survival in patients treated with this regimen.
* Determine the toxicity of this regimen in these patients.
OUTLINE: This is an open-label, non-randomized study.
Patients receive irinotecan IV over 30 minutes and flavopiridol IV over 1 hour on days 1, 8, 15, and 22. Courses repeat every 42 days in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 16-32 patients will be accrued for this study within 2 years.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Memorial Sloan-Kettering Cancer Center
🇺🇸New York, New York, United States