A Study of Efficacy and Safety of Mongersen (GED-0301) for the Treatment of Adult and Adolescent Subjects With Active Crohn's Disease
- Registration Number
- NCT02974322
- Lead Sponsor
- Celgene
- Brief Summary
The purpose of study is to test the effect of an experimental medication GED-0301(mongersen) and evaluate its safety in patients (≥ 12 years of age) with active Crohn's disease. The study will test GED-0301 compare to placebo for 12 weeks. The study treatment is blinded which means that patients and the study doctor will not know which treatment has been assigned. Patients in this study will be allowed treatment with stable doses of oral aminosalicylates, oral corticosteroids, immunosupressants and antibiotics for the treatment of Crohn's disease. Adolescent patients will also be allowed treatment with stable doses of exclusive enteral nutrition and growth hormone.
All patients who complete the study will have the option to enter a long term active treatment study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Subjects must satisfy the following criteria to be enrolled in the study:
- Male or female ≥ 12 years
- Subject is able to swallow the IP tablets
- Active Crohn's disease (CD) disease as determined by the Crohn's Disease Activity Index (CDAI) score and the Simple Endoscopic Score for Crohn's Disease (SES-CD)
- Must meet a determined average minimum number of daily stools or rating of abdominal pain over a 7day period
- Subject must have failed or experienced intolerance to at least one of the following: budesonide; systemic corticosteroids; immunosuppressants (eg, azathiopurine, 6-mercaptopurine, or methotrexate); or biologics for the treatment of CD (ie, infliximab, adalimumab, certolizumab, or vedolizumab).
• The presence of any of the following will exclude a subject from enrollment: Diagnosis of ulcerative colitis (UC), indeterminate colitis, ischemic colitis, microscopic colitis, radiation colitis or diverticular disease-associated colitis, or colitis due to immunodeficiency
- Local manifestations of Crohn's Disease (CD) such as abscesses, short bowel syndrome; or other disease complications for which surgery might be indicated or could confound the evaluation of efficacy
- Subject has strictures with prestenotic dilatation, requiring procedural intervention, or with obstructive symptoms. In addition, subjects with colonic strictures that are not passable with an age-appropriate colonoscope, or strictures in the ileum or ileocecal valve that are fibrotic in nature, will be excluded
- Intestinal resection within 6 months or any intra-abdominal surgery within 3 months prior to the Screening Visit
- Ileostomy or a colostomy
- Subject has a history of any clinically significant medical condition that, in the investigator's opinion, would prevent the subject from participating in the study
- Adolescents with delayed growth or pubertal development who are on corticosteroids at baseline and who should not continue treatment with the same dose of corticosteroids until the Week 12 visit.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo once daily Placebo Placebo once daily (QD) GED-0301 1 x 160 mg once daily GED-0301 GED-0301 1 x 160 mg tablet once daily (QD) GED-0301 - 4 x 40 mg once daily GED-0301 GED-0301 4 x 40 mg tablets once daily (QD)
- Primary Outcome Measures
Name Time Method Clinical remission defined by an average daily liquid or soft stool frequency and abdominal pain score (US) and Crohn's Disease Activity Index (CDAI) (Rest of World) week 12 The proportion of subjects achieving clinical remission at Week 12.
- Secondary Outcome Measures
Name Time Method Clinical remission defined by an average daily liquid or soft stool frequency and abdominal pain score (US) and CDAI Week 4, week 12 The proportion of subjects achieving clinical remission at Week 4, Week 12.
Clinical response defined by CDAI Week 4, week 12 The proportion of subjects achieving clinical response at Week 4, Week 12.
Pharmacokinetics (PK)- plasma concentration of GED-0301 Week 4, week 8 The plasma concentration of GED-0301 at Week 4, Week 8
Endoscopic improvement by the Simple Endoscopic Score for Crohn's Disease (SES-CD) Week 12 Endoscopic improvement of the mucosa at Week 12.
Clinical remission defined by PCDAI Week 12 The proportion of subjects achieving clinical remission at Week 12 (adolescent subjects only).
Adverse Events (AEs) Up to 20 weeks Incidence and severity of adverse events
Trial Locations
- Locations (308)
UMass Medical Center
🇺🇸Worcester, Massachusetts, United States
Henry Ford Health System
🇺🇸Novi, Michigan, United States
High Desert Gastroenterology, Inc.
🇺🇸Lancaster, California, United States
University of Maryland Medical Group
🇺🇸Baltimore, Maryland, United States
Shafran Gastroenterology Center
🇺🇸Winter Park, Florida, United States
Louisiana Research Center LLC
🇺🇸Shreveport, Louisiana, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
The Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Helsingin yliopistollinen keskussairaala
🇫🇮Helsinki, Finland
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
Swedish Medical Center Cancer Institute Research
🇺🇸Seattle, Washington, United States
University of Miami
🇺🇸Miami, Florida, United States
Advance Medical Research Center
🇺🇸Miami, Florida, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
Gulf Coast Research Group LLC
🇺🇸Houston, Texas, United States
Methodist Hospital
🇺🇸Houston, Texas, United States
Houston Endoscopy and Research Center
🇺🇸Houston, Texas, United States
Medical Associates Research Group Inc.
🇺🇸San Diego, California, United States
Consultants for Clinical Research Inc.
🇺🇸Cincinnati, Ohio, United States
Phoenix Childrens Hospital
🇺🇸Phoenix, Arizona, United States
University of California at San Francisco (PARENT)
🇺🇸San Francisco, California, United States
Oklahoma Foundation for Digestive Research
🇺🇸Oklahoma City, Oklahoma, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Hvidovre Hospital
🇩🇰Hvidovre, Denmark
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
🇮🇹Rome, Italy
Universita Campus Bio-Medico di Roma
🇮🇹Roma, Italy
Complesso Integrato Columbus
🇮🇹Roma, Italy
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju-Si, Korea, Republic of
Gastroenterologische Praxis Minden
🇩🇪Minden, Germany
EUGASTRO GmbH
🇩🇪Leipzig, Germany
Hepato-Gastroenterologie HK, s. r. o.
🇨🇿Hradec Králové, Czechia
CCBR Prague CZ
🇨🇿Praha 3, Czechia
Ballarat Base Hospital
🇦🇺Ballarat, Australia
Arizona Digestive Health
🇺🇸Sun City, Arizona, United States
University of Southern California Medical Center
🇺🇸Los Angeles, California, United States
Cleveland Clinic Florida Weston
🇺🇸Weston, Florida, United States
Graves Gilbert Clinic
🇺🇸Bowling Green, Kentucky, United States
Connecticut GI PC Research Division
🇺🇸Hartford, Connecticut, United States
Sanitas Research
🇺🇸Miami, Florida, United States
Gastroenterology Associates PA
🇺🇸Little Rock, Arkansas, United States
Florida Center for Gastroenterology
🇺🇸Largo, Florida, United States
Valley View Internal Medicine
🇺🇸Garden Grove, California, United States
Iowa Digestive Disease Center
🇺🇸Clive, Iowa, United States
HCP Clinical Research LLC
🇺🇸Torrance, California, United States
Georgia Regents University
🇺🇸Augusta, Georgia, United States
Northwestern University-Feinberg School of Medicine
🇺🇸Chicago, Illinois, United States
Ventura Clinical Trials
🇺🇸Ventura, California, United States
Columbus Regional Research Institute
🇺🇸Columbus, Georgia, United States
Atlanta Gastroenterology Specialists PC
🇺🇸Suwanee, Georgia, United States
University of Kentucky Medical Center
🇺🇸Lexington, Kentucky, United States
Johns Hopkins University School of Medicine
🇺🇸Baltimore, Maryland, United States
Charm City Research Group
🇺🇸Towson, Maryland, United States
Ehrhardt Clinical Research, LLC
🇺🇸Belton, Missouri, United States
Jefferson City Medical Group
🇺🇸Jefferson City, Missouri, United States
The Feinstein Institute for Medical Research PRIME
🇺🇸Manhasset, New York, United States
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Childrens Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Charlottesville Medical Research Center
🇺🇸Charlottesville, Virginia, United States
Dean Clinic Oregon
🇺🇸Madison, Wisconsin, United States
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Centre For Digestive Diseases
🇦🇺Five Dock, New South Wales, Australia
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Mater Adult Hospital
🇦🇺South Brisbane, Queensland, Australia
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
Klinikum Klagenfurt am Wörtersee
🇦🇹Klagenfurt, Austria
LKH - Universitätsklinikum der PMU Salzburg
🇦🇹Salzburg, Austria
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Alberta Childrens Hospital
🇨🇦Calgary, Alberta, Canada
Krankenanstalt Rudolfstiftung Wien
🇦🇹Wein, Austria
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
UZ Antwerpen
🇧🇪Edegem, Belgium
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Royal Adelaide Hospital Institute of Medical and Veterinary Science
🇦🇺Adelaide, South Australia, Australia
Hopital Universitaire des Enfants
🇧🇪Brussels, Belgium
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
Monash Medical Centre Clayton
🇦🇺Bentleigh East, Australia
Barrie GI Associates
🇨🇦Barrie, Ontario, Canada
GI Research Institute
🇨🇦Vancouver, British Columbia, Canada
LHSC - Victoria Hospital
🇨🇦London, Ontario, Canada
St Vincents Hospital Melbourne
🇦🇺Fitzroy, Australia
Aarhus Universitetshospital
🇩🇰Aahus C, Denmark
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
CHU Sart Tilman
🇧🇪Liege, Belgium
Royal University Hospital
🇨🇦Saskatoon, Saskatchewan, Canada
Mount Sinai Hospital
🇨🇦Toronto, Ontario, Canada
Koge Sygehus
🇩🇰Koge, Denmark
PreventaMed
🇨🇿Olomouc, Czechia
Alborg Universitets Hospital
🇩🇰Alborg, Denmark
Crohn Colitis Centrum Rhein Main
🇩🇪Frankfurt, Germany
CHU de Rouen Hopital Charles Nicolle
🇫🇷Rouen, France
Thomayerova nemocnice
🇨🇿Praha 4, Czechia
CHU Amiens Hopital Sud
🇫🇷Amiens Cedex, France
Hopital Saint Louis
🇫🇷Paris Cedex 10, France
Odense Universitetshospital
🇩🇰Odense C, Denmark
Regionshospitalet Silkeborg
🇩🇰Silkeborg, Denmark
Hopital Nord CHU Marseille
🇫🇷Marseille cedex 20, France
Centre Hospitalier Lyon Sud
🇫🇷Pierre Benite cedex, France
Hopital Claude Huriez CHRU Lille
🇫🇷Lille cedex, France
Tampereen yliopistollinen sairaala
🇫🇮Tampere, Finland
CHU Nice Hopital de lArchet 2
🇫🇷Nice Cedex 3, France
CHU Reims Hopital Robert Debre
🇫🇷Reims, France
Azienda Ospedaliera Di Padova
🇮🇹Padova, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Italy
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi dAragona
🇮🇹Salerno, Italy
CHA Bundang Medical Center CHA University
🇰🇷Seongnam-si,, Korea, Republic of
St. Josef-Hospital
🇩🇪Bochum, Germany
Kaplan Medical Center
🇮🇱Rechovot, Israel
Katholische Kliniken Ruhrhalbinsel GmbH
🇩🇪Essen, Germany
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Szent-Gyorgyi Albert TE AOK Borgyogy
🇭🇺Szeged, Hungary
Universitaetsklinikum EssenZentrum fuer Innere Medizin
🇩🇪Essen, Germany
University General Hospital of Patras
🇬🇷Rio Patras, Greece
Fondazione IRCCS Policlinico San Matteo
🇮🇹Pavia, Italy
Azienda Ospedaliera San Camillo Forlanini
🇮🇹Rome, Italy
IRCCS Policlinico San Donato
🇮🇹San Donato Milanese, Italy
Charite - Campus Virchow-Klinikum
🇩🇪Berlin, Germany
DRK Kliniken Berlin Westend
🇩🇪Berlin, Germany
Rabin Medical Center
🇮🇱Petah Tikva, Israel
Universitaetsklinikum Erlangen
🇩🇪Erlangen, Germany
Universitatsklinikum Regensburg
🇩🇪Regensburg, Germany
Obudai Egeszsegugyi Centrum Kft.
🇭🇺Budapest, Hungary
Hopital de Brabois Adultes
🇫🇷Vandoeuvre les Nancy, France
Ewha Womans University Mokdong Hospital
🇰🇷Seoul, Korea, Republic of
Universitaetsklinikum Ulm
🇩🇪Ulm, Germany
Staedisches Klinikum Brandenburg
🇩🇪Brandenburg an der Havel, Germany
Kliniken Essen-Mitte
🇩🇪Essen, Germany
Asklepios Klinik Hamburg
🇩🇪Hamburg, Germany
Athens Medical Center
🇬🇷Athens, Greece
Azienda Ospedaliera Universitaria Policlinico Sant Orsola Malpighi
🇮🇹Bologna, Italy
General Hospital of Athens Evangelismos
🇬🇷Athens, Greece
Fondazione IRCCS CA Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Azienda Ospedaliera Vincenzo Cervello
🇮🇹Palermo, Italy
Assaf Harofeh Medical Center
🇮🇱Zerifin, Israel
Digestive Diseases Center Gastro
🇱🇻Riga, Latvia
Riga East Clinical University Hospital clinic Gailezers
🇱🇻Riga, Latvia
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Danderyds Sjukhus AB
🇸🇪Stockholm, Sweden
Hanyang Univerisy Guri Hospital
🇰🇷Guri-si, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Centrum Medyczne A-Z Clinic
🇵🇱Kraków, Poland
LexMedica Osrodek Badan Klinicznych
🇵🇱Wroclaw, Poland
Hospital da Senhora da Oliveira Guimaraes
🇵🇹Guimaraes, Portugal
CMI Dr. Tirnaveanu Amelita
🇷🇴Oradea, Romania
Hacettepe University Medical Faculty
🇹🇷Ankara, Turkey
Amphia Ziekenhuis
🇳🇱Breda, Netherlands
Hospital Universitario de la Princessa
🇪🇸Madrid, Spain
SP ZOZ Wojewodzki Szpital Zespolony im. J. Sniadeckiego
🇵🇱Bialystok, Poland
Centrum Medyczne AMED
🇵🇱Lodz, Poland
Nzoz Vivamed
🇵🇱Warsaw, Poland
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Da Luz
🇵🇹Lisboa, Portugal
Centrul de Gastroenterologie Dr. Goldis
🇷🇴Timisoara, Romania
Inselspital - Universitaetsspital Bern
🇨🇭Bern, Switzerland
SPb SBIH City Hospital # 26
🇷🇺Saint-Petersburg, Russian Federation
CI of SRC Sumy RCH Dept of Rheumatology Sumy SU MI
🇺🇦Sumy, Ukraine
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Ankara University Medical Faculty
🇹🇷Ankara, Turkey
Centro Hospitalar de Sao Joao, EPE
🇵🇹Porto, Portugal
Centro Hospitalar do Alto Minho - Unidade Local de Saúde do Alto Minho, EPE
🇵🇹Viana do Castelo, Portugal
Hopitaux Universitaires de Geneve-HUG
🇨🇭Geneva, Switzerland
NonState Healthcare Institution Central Clinical Hospital, Samara station JSC Russian Railways
🇷🇺Samara, Russian Federation
Medical Center Stolitsa-Medikl
🇷🇺Moscow, Russian Federation
SBEIHPE Novosibirsk State Medical University
🇷🇺Novosibirsk, Russian Federation
Hospital de Braga
🇵🇹Braga, Portugal
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Clinical Center Bezanijska Kosa
🇷🇸Belgrade, Serbia
Crohn-Colitis Zentrum Bern Gemeinschaftspraxis Balsiger Seibold und Partner
🇨🇭Bern, Switzerland
Complejo Hospitalario de Pontevedra
🇪🇸Pontevedra, Spain
Firat University Medical Faculty
🇹🇷Elazig, Turkey
UniversitatSspital Zurich
🇨🇭Zuerich, Switzerland
SRI of Invalid Rehabilitation EST Complex of Vinnytsia M.I.Pyrogov NMU MOHU
🇺🇦Vinnytsia, Ukraine
Marmara University Pendik Training and Research Hospital
🇹🇷Istanbul, Turkey
Inonu Uni. Med. Fac.
🇹🇷Malatya, Turkey
Royal London Hospital
🇬🇧London, United Kingdom
CI Odesa Regional Clinical Hospital
🇺🇦Odessa, Ukraine
Ternopil City Communal Emergency Medical Care Hospital
🇺🇦Ternopil, Ukraine
Borders General Hospital
🇬🇧Roxburghshire, United Kingdom
Manchester Royal Infirmary
🇬🇧Manchester, United Kingdom
Basingstoke and North Hampshire Hospital
🇬🇧Basingstoke, United Kingdom
University Hospital Coventry
🇬🇧Coventry, United Kingdom
Nottingham University Hospitals Queens Medical Centre
🇬🇧Nottingham, United Kingdom
Hull Royal Infirmary
🇬🇧Hull, United Kingdom
University College London Hospitals
🇬🇧London, United Kingdom
Cedars Sinai Medical Center
🇺🇸Los Angeles, California, United States
Dcr-Pi Pc
🇺🇸Litchfield Park, Arizona, United States
Northshore University Healthsystem Research Institute
🇺🇸Evanston, Illinois, United States
Lahey Clinic Inc. - PARENT ACCOUNT
🇺🇸Burlington, Massachusetts, United States
Semmelweis Egyetem
🇭🇺Budapest, Hungary
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon-si, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Universitaetsklinikum Schleswig Holstein Campus Kiel
🇩🇪Kiel, Germany
Saint Louis University
🇺🇸Saint Louis, Missouri, United States
Hunter Holmes Mcguire Ctr
🇺🇸Richmond, Virginia, United States
Facey Medical Foundation
🇺🇸Mission Hills, California, United States
Mayo Clinic Arizona
🇺🇸Scottsdale, Arizona, United States
Medical Research Center of Connecticut LLC
🇺🇸Hamden, Connecticut, United States
Innovative Clinical Research
🇺🇸Lafayette, Colorado, United States
Connecticut Gastroenterology Institute
🇺🇸Bristol, Connecticut, United States
Mayo Clinic - Jacksonville
🇺🇸Jacksonville, Florida, United States
Galiz Research LLC
🇺🇸Miami Springs, Florida, United States
Advanced Medical Research Center
🇺🇸Port Orange, Florida, United States
Cordova Research Institute
🇺🇸Miami, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
East Coast Institute for Research LLC
🇺🇸Saint Augustine, Florida, United States
Health Science Research Center, LLC
🇺🇸Pratt, Kansas, United States
Heartland Research Associates LLC
🇺🇸Wichita, Kansas, United States
Via Christi Research a division of Via Christi Hospitals Wichita Inc
🇺🇸Wichita, Kansas, United States
Clinical Trials of SW Louisiana LLC
🇺🇸Lake Charles, Louisiana, United States
Gastroenterology Associates, LLC
🇺🇸Baton Rouge, Louisiana, United States
Medex Research Institute
🇺🇸Caro, Michigan, United States
Gastroenterology Associates of Western Michigan PLC
🇺🇸Wyoming, Michigan, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Mercy Research
🇺🇸Washington, Missouri, United States
AGA Clinical Research Associates LLC
🇺🇸Egg Harbor Township, New Jersey, United States
NYU Langone Long Island Clinical Research Associates
🇺🇸Great Neck, New York, United States
North Shore-LIJ Health System-Division of Rheumatology
🇺🇸Great Neck, New York, United States
Montefiore Medical Center PRIME
🇺🇸Lake Success, New York, United States
New York University School of Medicine
🇺🇸New York, New York, United States
Winthrop University Hospital
🇺🇸Mineola, New York, United States
Columbia University Medical Center
🇺🇸New York, New York, United States
University of Rochester
🇺🇸Rochester, New York, United States
Mount Sinai School of Medicine
🇺🇸New York, New York, United States
Premier Medical Group of the Hudson Valley PC
🇺🇸Poughkeepsie, New York, United States
Carolina Center for Liver Disease
🇺🇸Charlotte, North Carolina, United States
Asheville Gastroenterology Associates, P.A.
🇺🇸Asheville, North Carolina, United States
Gaffney Health Services
🇺🇸Charlotte, North Carolina, United States
PhysiqueMed Clinical Trials
🇺🇸Greensboro, North Carolina, United States
Kinston Medical Specialists PA
🇺🇸Kinston, North Carolina, United States
Clinical Inquest Center Ltd
🇺🇸Beavercreek, Ohio, United States
Trial Management Associates LLC
🇺🇸Wilmington, North Carolina, United States
Clinical Trials of America, LLC
🇺🇸Mount Airy, North Carolina, United States
UC Health Clinical Trials Office
🇺🇸Cincinnati, Ohio, United States
Ohio Clinical Research Partners LLC
🇺🇸Akron, Ohio, United States
Dr. Deepak Sarwal, MD
🇺🇸Centerville, Ohio, United States
Springfield Health Care Center
🇺🇸Springfield, Ohio, United States
Drexel University College of Medicine
🇺🇸Philadelphia, Pennsylvania, United States
Main Line Gastroenterology
🇺🇸Havertown, Pennsylvania, United States
University of Pennsylvania School of Medicine
🇺🇸Philadelphia, Pennsylvania, United States
Penn State University Milton S Hershey Medical Center
🇺🇸State College, Pennsylvania, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
ClinSearch LLC
🇺🇸Chattanooga, Tennessee, United States
Texas Clinical Research Institute LLC
🇺🇸Arlington, Texas, United States
University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States
Digestive Health Center
🇺🇸Pasadena, Texas, United States
Texas Digestive Disease Consultants - Southlake
🇺🇸Southlake, Texas, United States
Digestive Health Specialists of Tyler
🇺🇸Tyler, Texas, United States
University of Utah Division of Gastroenterology
🇺🇸Salt Lake City, Utah, United States
Advanced Clinical Research
🇺🇸West Jordan, Utah, United States
University of Virginia
🇺🇸Charlottesville, Virginia, United States
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
University of Wisconsin Hospital and Clinics
🇺🇸Madison, Wisconsin, United States
Digestive and Liver Disease Specialists
🇺🇸Norfolk, Virginia, United States
University of Washington School of Medicine
🇺🇸Seattle, Washington, United States
Harborview Medical Center
🇺🇸Seattle, Washington, United States
The Vancouver Clinic
🇺🇸Vancouver, Washington, United States
Centre de sante et de services sociaux Champlain Charles Le Moyne
🇨🇦Greenfield Park, Quebec, Canada
The Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
CHU Besancon Hopital Jean Minjoz
🇫🇷Besancon Cedex, France
CHU de Toulouse Hopital Rangueil
🇫🇷Toulouse Cedex 09, France
Universitaetsklinikum Carl Gustav Carus
🇩🇪Dresden, Germany
Szent Margit Korhaz
🇭🇺Budapest, Hungary
HELIOS Klinikum Wuppertal
🇩🇪Wuppertal, Germany
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
FSBI Scientific Research Institute of Physyology and Basic Medicine under the SB of RAMS
🇷🇺Novosibirsk, Russian Federation
Gazi University Medical Faculty
🇹🇷Ankara, Turkey
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Spain
Turkiye Yuksek Ihtisas Hospital
🇹🇷Ankara, Turkey
Acibadem Fulya Hospital
🇹🇷Istanbul, Turkey
Istanbul University Cerrahpasa Medical Faculty
🇹🇷Istanbul, Turkey
Ege University Medical Faculty
🇹🇷Izmir, Turkey
Haydarpasa Numune Training and Research Hospital
🇹🇷Istanbul, Turkey
Mersin University Medical Faculty
🇹🇷Mersin, Turkey
CI of PH Kharkiv CCH #2
🇺🇦Kharkiv, Ukraine
Dokuz Eylul University Izmir
🇹🇷Izmir, Turkey
Istanbul Medeniyet Uni Goztepe Training&Res Hosp
🇹🇷Istanbul, Turkey
Kocaeli Derince Training and Research Hospital
🇹🇷Kocaeli, Turkey
Treatment-Diagnostic Center of Private Enterprise of PMF Atsynus
🇺🇦Kirovohrad, Ukraine
Queen Elizabeth University Hospital
🇬🇧Glasgow, United Kingdom
Clinical Hospital Centre Osijek
🇭🇷Osijek, Croatia
GASTRO I., s.r.o.
🇸🇰Presov, Slovakia
University Of Colorado
🇺🇸Aurora, Colorado, United States
GCRM
🇺🇸Orlando, Florida, United States
Yale University
🇺🇸New Haven, Connecticut, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Clinical Research of West Florida, Inc.
🇺🇸Tampa, Florida, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
Center For Digestive Health
🇺🇸Orlando, Florida, United States
University of Michigan Health System
🇺🇸Ann Arbor, Michigan, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
PMG Research of Winston-Salem
🇺🇸Winston-Salem, North Carolina, United States
Oregon Health & Science University
🇺🇸Portland, Oregon, United States
Carolinas Healthcare System
🇺🇸Charleston, South Carolina, United States
Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Kyiv City Clinical Hospital #1
🇺🇦Kyiv, Ukraine
SI Branch CH of Zaporizhzhia Station-2 of SE Prydniprovska Railway Dept of Surgery Zaporizhzhia SMU
🇺🇦Zaporizhia, Ukraine
Clinsante S.C. Osrodek Badan Klinicznych
🇵🇱Bydgoszcz, Poland
CI Zaporizhzhia Regional Clinical Hospital of ZRC
🇺🇦Zaporozhje, Ukraine
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States