Improvised Explosive Device (IED) Level Blasting of Human Blood With Slosh Prevention
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 40
- Locations
- 2
- Primary Endpoint
- Lysis of blood cells
Study Overview
Brief Summary
To monitor changes in indicators of red cell damage such as extracellular hemoglobin, potassium (K-ABL), and lactate dehydrogenase (LD) post blast exposure.
Detailed Description
Traumatic brain injury (TBI) causes significant morbidity and mortality, accompanied by high related costs. Recent hypotheses concerning the pathophysiology of TBI invoke Strain Shear Theory and Cavitation Theory. The invbestigators propose to test the importance of the latter by directing blast waves into containers that are either partially or completely filled with blood and measuring markers of lysis.
These experiments are designed to better understand the demonstrated effectiveness of mild jugular compression according to the principle of the Queckenstedt Maneuver to reduce the likelihood of TBI by filling up the compliance of the cranial space. A device (C-Collar) is being developed by Q30 Labs, LLC (Q30), to accomplish this effect.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •• Normal healthy volunteer
- •Able to provide written consent
- •Must be 18 years or older
Exclusion Criteria
- •• Unable to provide written consent
- •Recent penetrating brain trauma (within 6 months)
- •Under the age of 18 years
Outcomes
Primary Outcomes
Lysis of blood cells
Time Frame: within 2 hours
measure the lysis of blood cells exposed to blast from CO2 cartridge
Secondary Outcomes
No secondary outcomes reported