Improvised Explosive Device (IED) Level Blasting of Human Blood With Slosh Prevention
- Conditions
- Brain Injuries
- Interventions
- Other: blood draw
- Registration Number
- NCT03018548
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Brief Summary
To monitor changes in indicators of red cell damage such as extracellular hemoglobin, potassium (K-ABL), and lactate dehydrogenase (LD) post blast exposure.
- Detailed Description
Traumatic brain injury (TBI) causes significant morbidity and mortality, accompanied by high related costs. Recent hypotheses concerning the pathophysiology of TBI invoke Strain Shear Theory and Cavitation Theory. The invbestigators propose to test the importance of the latter by directing blast waves into containers that are either partially or completely filled with blood and measuring markers of lysis.
These experiments are designed to better understand the demonstrated effectiveness of mild jugular compression according to the principle of the Queckenstedt Maneuver to reduce the likelihood of TBI by filling up the compliance of the cranial space. A device (C-Collar) is being developed by Q30 Labs, LLC (Q30), to accomplish this effect.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
-
• Normal healthy volunteer
- Able to provide written consent
- Must be 18 years or older
-
• Unable to provide written consent
- Recent penetrating brain trauma (within 6 months)
- Under the age of 18 years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description subject blood drawns blood draw subjects will have blood drawn which will then be exposed to blast via CO2 cartridge
- Primary Outcome Measures
Name Time Method Lysis of blood cells within 2 hours measure the lysis of blood cells exposed to blast from CO2 cartridge
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cincinnati Childrens Hospital Medical Center
🇺🇸Cincinnati, Ohio, United States