Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.
- Conditions
- Metastatic Colorectal Cancer
- Interventions
- Drug: Trifluridine/tipiracil hydrochloride (S95005)
- Registration Number
- NCT03869892
- Lead Sponsor
- Institut de Recherches Internationales Servier
- Brief Summary
The main purpose of this study is to demonstrate the superiority of S 95005 in combination with bevacizumab over capecitabine in combination with bevacizumab.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 856
- Has definitive histologically confirmed adenocarcinoma of the colon or rectum (all other histological types are excluded). Primary tumour localisation must be known.
- RAS status based on local biological assessment of tumour biopsy must be available. If RAS status is not available at the time of randomisation, tumour biopsy must be available for RAS status determination (based on local biological assessment).
- Patient is not a candidate for standard full dose combination chemotherapy with irinotecan or oxaliplatin
- Patient is not a candidate for curative resection of metastatic lesions.
- No previous systemic anticancer therapy for unresectable metastatic colorectal cancer.
- ECOG (Eastern Cooperative Oncology Group) performance status ≤2.
- Adequate organ function (renal, haematological, hepatic, coagulation) as described in the study protocol'
-
Pregnancy, breastfeeding or possibility of becoming pregnant during the study.
-
Participation in another interventional study within 4 weeks prior to the randomisation .
-
Patients who have not recovered from clinically relevant non-hematologic CTCAE grade ≥ 3 toxicity of previous anticancer therapy prior to the randomisation.
-
Symptomatic central nervous system metastases.
-
Major surgery within 4 weeks prior to the randomisation.
Exclusion criteria related to S 95005 administration:
-
History of allergic reactions attributed to compounds of similar composition to S 95005 or any of its excipients.
-
Any contraindication present in the SmPC of trifluridine/tipiracil
Exclusion criteria related to bevacizumab administration:
-
Any contraindication present in the SmPC of bevacizumab
Exclusion criteria related to capecitabine administration:
-
Any contraindication present in the SmPC of capecitabine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description S95005 + Bevacizumab Trifluridine/tipiracil hydrochloride (S95005) - S95005 + Bevacizumab Bevacizumab experimental - Capecitabine + Bevacizumab Capecitabine - Capecitabine + Bevacizumab Bevacizumab control -
- Primary Outcome Measures
Name Time Method Progression-free Survival (PFS) Up to 24 months Time elapsed between the randomization and the date of radiological tumour progression (according to RECIST 1.1) or death from any cause.
- Secondary Outcome Measures
Name Time Method Overall Survival (OS) Up to 24 months Time elapsed between the date of randomization and the date of death due to any cause.
Overall response rate (ORR) Up to 24 months The proportion of patients with objective evidence of complete response (CR) or partial response (PR) according to RECIST 1.1 criteria and using investigator's tumour assessment.
Disease control rate (DCR) Up to 24 months The proportion of patients with objective evidence of CR or PR or stable disease (SD) according to RECIST 1.1 criteria and using investigator's tumour assessment.
Duration of response (DoR) Up to 24 months The time from the first documentation of response (CR or PR) to the first documentation of objective tumour progression or death due to any cause, whichever occurs first.
Time to treatment failure (TTF) Up to 24 months The time from randomization to treatment discontinuation for any reason, including disease progression, treatment toxicity, patient preference, or death.
Trial Locations
- Locations (189)
Lake Macquarie Private Hospital
🇦🇺Gateshead, Australia
Hospital de Base Centro Integrado de Pesquisa
🇧🇷São José Do Rio Preto, Brazil
The Adelaide and Meath Hospital
🇮🇪Dublin, Ireland
Masarykuv onkologicky ustav Klinika komplexni onkologicke pece
🇨🇿Brno, Czechia
Del-Pesti Centrumkh-Orsz. Hematologiai es Infektologiai Int. Szent Laszlo Telephely
🇭🇺Budapest, Hungary
Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj Napoca Oncologie Medicala
🇷🇴Cluj-Napoca, Romania
H. Universitario La Paz Oncología Médica
🇪🇸Madrid, Spain
Hospital Universitario Marqués de Valdecilla Oncología médica
🇪🇸Santander, Spain
Lanssjukhuset Ryhov Onkologiska kliniken
🇸🇪Jönköping, Sweden
Hospital Quirónsalud Valencia Servicio de Oncología Médica
🇪🇸Valencia, Spain
MI "Dnipropetrovsk City Multi-field Clinical Hospital #4" Department of Oncology
🇺🇦Dnipro, Ukraine
National Institute of Cancer Abdominal Oncology Department
🇺🇦Kyiv, Ukraine
Karolinska University Hospital, Solna Studiebehandlingsenheten, B8:09
🇸🇪Solna, Sweden
Albert Schweitzer Ziekenhuis Interne Geneeskunde
🇳🇱Dordrecht, Netherlands
Catharina Ziekenhuis Interne Gesneeskunde/Oncologie
🇳🇱Eindhoven, Netherlands
Odense Universitetshospital Onkologisk Afdeling R
🇩🇰Odense, Denmark
Istituto Oncologico Veneto IOV - IRCCS Unità Operativa Complessa Oncologia Medica 1
🇮🇹Padova, Italy
University Hospitals Bristol Bristol Haematology & Oncology Centre
🇬🇧Bristol, United Kingdom
Royal Marsden Hospital Department of Medicine
🇬🇧Sutton, United Kingdom
Hammersmith Hospital Gary Weston Centre
🇬🇧London, United Kingdom
Sarah Cannon Research Institute UK Clinical Trials
🇬🇧London, United Kingdom
Pecsi Tudomanyegyetem, Klinikai Kozpont Onkoterapias Intezet
🇭🇺Pécs, Hungary
Zala Megyei Korhaz Onkologiai osztaly
🇭🇺Zalaegerszeg, Hungary
Szabolcs-Szatmar-Bereg Megyei Korhazak Onkoradiologiai Osztaly
🇭🇺Nyíregyháza, Hungary
Centro de Oncología e Investigación de Buenos Aires COIBA
🇦🇷Berazategui, Argentina
Hospital Universitario CEMIC Servicio de Oncología, Unidad de tumores gastrointestinales
🇦🇷Ciudad Autonoma de Buenos aires, Argentina
Instituto Alexander Fleming
🇦🇷Ciudad Autonoma de Buenos aires, Argentina
Fundación Favaloro Oncology Unit
🇦🇷Buenos Aires, Argentina
Hospital de Gastroenterología Dr. Carlos Borino Udaondo Oncology Unit
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Centro Oncológico Riojano Integral CORI Fundación CORI para la Investigación y Prevención del Cáncer
🇦🇷La Rioja, Argentina
Fundación COIR Centro Oncológico de Interación Regional
🇦🇷Mendoza, Argentina
Instituto de Oncología de Rosario
🇦🇷Santa Fe, Argentina
ISIS Centro especializado
🇦🇷Santa Fe, Argentina
Blacktown Hospital Cancer and Haematology Centre
🇦🇺Blacktown, Australia
Frankston Private Peninsula and Southeast Oncology Group
🇦🇺Frankston, Australia
Centro Médico San Roque
🇦🇷Tucumán, Argentina
Adventist HealthCare Integrated Cancer Centre
🇦🇺Wahroonga, Australia
St George Hospital St George Hospital Cancer Care Centre
🇦🇺Kogarah, Australia
Southern Medical Day Care Centre
🇦🇺Wollongong, Australia
Med. Universität Graz Klinische Abteilung für Onkologie
🇦🇹Graz, Austria
Medizinische Universität Innsbruck Univ.-Klinik für Innere Medizin V
🇦🇹Innsbruck, Austria
Ordensklinikum Linz Barmherzige Schwestern Interne I
🇦🇹Linz, Austria
Allgemeines Krankenhaus - Universitätskliniken Klinische Abteilung für Onkologie
🇦🇹Wien, Austria
Hospital do Câncer de Barretos - Fundação Pio XII Unidade de Pesquisa Clínica
🇧🇷Barretos, Brazil
Landeskrankenhaus (SALK) Universitätsklinik für Innere Medizin III (SALK)
🇦🇹Salzburg, Austria
Cenantron - Clinica
🇧🇷Belo Horizonte, Brazil
Hospital São Rafael Centro Intergrado de Pesquisa
🇧🇷Salvador, Brazil
MHAT Serdika EOOD Department of Medical Oncology
🇧🇬Sofia, Bulgaria
"Medical Center Nadezhda Clinical" EOOD Medical Oncology Department
🇧🇬Sofia, Bulgaria
"Multiprofile hosp. for active treatmen Dr. Tota Venkova" AD Department of medical oncology
🇧🇬Gabrovo, Bulgaria
"Complex oncology center - Burgas" EOOD Department of medical oncology
🇧🇬Burgas, Bulgaria
"Complex oncology center - Plovdiv" EOOD, IInd base Dpt. of Med. oncology and onc. diseases in gastroenterology
🇧🇬Plovdiv, Bulgaria
"UMHAT Sv. Ivan Rilski" EAD Clinic of clinical hematology, Dpt. of medical oncology
🇧🇬Sofia, Bulgaria
SHAT of oncology diseases Dr. Marko Antonov Markov" EOOD Department of medical oncology and palliative therapy
🇧🇬Varna, Bulgaria
Spec. hospital for active treatment of oncology dis. EOOD Department of medical oncology and palliative care
🇧🇬Sofia, Bulgaria
"Complex Ongology Center - Vratsa" EOOD Department of Medical oncology
🇧🇬Vratsa, Bulgaria
Fakultni nemocnice Ostrava Klinika onkologicka
🇨🇿Ostrava, Czechia
Thomayerova nemocnice Onkologicka klinika 1. LF UK a TN
🇨🇿Praha, Czechia
Fakultni nemocnice Olomouc Onkologicka klinika
🇨🇿Praha, Czechia
Vseobecna fakultni nemocnice Onkologicka klinika VFN a 1. LF UK
🇨🇿Praha, Czechia
Aalborg Universitetshospital, Syd Onkologisk Afdelin
🇩🇰Aalborg, Denmark
Rigshospitalet Onkologisk Klinik
🇩🇰Kobenhavn, Denmark
Regionshospitalet Herning, Hospitalsenheden Vest Onkologisk Afdeling
🇩🇰Herning, Denmark
East Tallinn Central Hospital Center of Oncology
🇪🇪Tallinn, Estonia
CHU Jean Minjoz Service d'oncologie médicale
🇫🇷Besancon, France
CHU Morvan Institut de Cancérologie et d'Hématologie
🇫🇷Brest, France
Hopital Privé Jean Mermoz Service de Gastro entérologie et d'Oncologie médicale
🇫🇷Lyon, France
Hospital Mae de Deus Oncologia
🇧🇷Porto Alegre, Brazil
Hôpital Nord Franche-Comté - Site du Mittan Service d'oncologie médicale
🇫🇷Montbeliard, France
Hôpital Saint-Antoine Service d'Oncologie Médicale
🇫🇷Paris, France
Centre Antoine Lacassagne Dpt d'Oncologie Médicale
🇫🇷Nice, France
Hôpital Européen Georges Pompidou Oncologie Hépatogastroenterologie-oncologie digestive
🇫🇷Paris, France
Hopital Haut-Leveque Hepato-gastroenterologie et oncologie digestive
🇫🇷Pessac, France
CHU Toulouse Rangueil Oncologie médicale digestive
🇫🇷Toulouse, France
Sirio Libanes DF - Centro de Oncologia de Braslia do Sirio- Centro Intergrado de Pesquisa
🇧🇷Brasília, Brazil
Centro de Pesquisa Hospital de Caridade de Ijuí Unidade de Pesquisa Clínica
🇧🇷Ijuí, Brazil
ICESP - Instituto do Câncer do Estado de São Paulo Centro Integrado de Pesquisa
🇧🇷São Paulo, Brazil
Onkologische Schwerpunktpraxis Kurfuerstendamm
🇩🇪Berlin, Germany
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncol Centro Intergrado de Pesquisa
🇧🇷Santo André, Brazil
Hospital A C Camargo Unidade de Pesquisa Clinica
🇧🇷São Paulo, Brazil
Institut Sainte Catherine
🇫🇷Avignon, France
Lübecker Onkologische Schwerpunktpraxis im Hochschulstadttei
🇩🇪Luebeck, Germany
Klinikum der Universität München Campus Großhadern, Medizinische Klinik und Poliklinik III
🇩🇪Muenchen, Germany
Magyar Honvedseg Egeszsegugyi Kozpont Onkologiai Osztaly
🇭🇺Budapest, Hungary
Semmelweis University Radiology and Oncotherapy Clinic
🇭🇺Budapest, Hungary
Szent Imre Egyetem Oktatokorhaz Klinikai Onkologia
🇭🇺Budapest, Hungary
Uzsoki Utcai Korhaz Onkoradiologiai Osztaly
🇭🇺Budapest, Hungary
Orszagos Onkologiai Intezet "B" Belgyogyaszati-Onkologiai O. Es Klin. Farmakologiai O.
🇭🇺Budapest, Hungary
Petz Aladar Megyei Oktato Korhaz Onkoradiologiai Osztaly
🇭🇺Győr, Hungary
Debreceni Egyetem Orvos es Egeszsegtudomanyi Centrum Onkologiai Intezet
🇭🇺Debrecen, Hungary
Bekes Megyei Kozponti Korhaz
🇭🇺Gyula, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kp. Onkoterápiás Klinika
🇭🇺Szeged, Hungary
JNSZ Megyei Hetenyi Geza Korhaz es Rendelointezet Megyei Onkologiai Centrum
🇭🇺Szolnok, Hungary
Bacs-Kiskun Megyei Korhaz Onkoradiologiai Kozpont
🇭🇺Kecskemét, Hungary
Azienda Policlinico Universitaria - Presidio Monserrato Oncologia Medica
🇮🇹Cagliari, Italy
Markusovsky Egyetemi Oktatokorhaz Onkoradiologiai Osztaly
🇭🇺Szombathely, Hungary
Istituto Nazionale Tumori I.R.C.C.S "Fondazione G. Pascale" Struttura Complessa di Oncologia Medica Addominale
🇮🇹Napoli, Italy
Ospedale San Carlo U.O. Oncologia Medica
🇮🇹Potenza, Italy
Azienda Socio Sanitaria Territoriale di Cremona ONCOLOGIA
🇮🇹Cremona, Italy
A.O.U. Pisana-Ospedale Santa Chiara U.O. di Oncologia Medica 2
🇮🇹Pisa, Italy
Policlinico Universitario Campus Biomedico UOC di Oncologia Medica
🇮🇹Roma, Italy
Arcispedale Santa Maria Nuova Unità di Oncologia
🇮🇹Reggio Emilia, Italy
Istituto Clinico Humanitas I.R.C.C.S Dipartimento di Oncologia Medica ed Ematologia
🇮🇹Rozzano (mi), Italy
IRCSS Casa Sollievo della Sofferenza Dipartimento Onco-Ematologia
🇮🇹San Giovanni Rotondo, Italy
P. Stradins Clinical University Hospital
🇱🇻Riga, Latvia
Riga East Univerity Hospital Oncology Centre of Latvia
🇱🇻Riga, Latvia
Oncology Hospital, Branch of Hospital of Lithuanian Uni. of Health Sciences Kauno klinikos
🇱🇹Kaunas, Lithuania
Hospital of Lithuania Univ of Health Sciences Kauno klinikos Oncology Institute
🇱🇹Kaunas, Lithuania
Ospedale S. Bortolo -ULSS8 Berica Distretto Est U.O. ONCOLOGIA
🇮🇹Vicenza, Italy
Rijnstate Oncologie
🇳🇱Arnhem, Netherlands
Ikazia Ziekenhuis Oncologie
🇳🇱Rotterdam, Netherlands
ETZ Elisabeth Interne Geneeskunde
🇳🇱Tilburg, Netherlands
Bernhoven Interne Geneeskunde
🇳🇱Uden, Netherlands
Uniwersyteckie Centrum Kliniczne Klinika Onkologii i Radioterapii
🇵🇱Gdańsk, Poland
NU-MED Centrum Diagnostyki i Terapii Onkologicznej Tomaszów Mazowiecki II Sp. z o.o., Pododdzial Chemioterapi
🇵🇱Tomaszów Mazowiecki, Poland
Wielkopolskie Centrum Onkologii im Marii Sklodowskiej-Curie Oddzial Chemioterapii
🇵🇱Poznań, Poland
M. Kopernika Provincial Hospital Oddzial Chemioterapii Nowotworow
🇵🇱Łódź, Poland
Hospital Garcia de Orta Serviço de Oncologia Médica
🇵🇹Almada, Portugal
Centro Hospitalar e Universitário de Coimbra - CHUC Unidade de Inovação e Desenvolvimento (UID)
🇵🇹Coimbra, Portugal
Centro Hospitalar Lisboa Norte, Hospital de Santa Maria Serviço de Oncologia Médica
🇵🇹Lisboa, Portugal
Instituto Português de Oncologia do Porto FG, EPE -IPO Porto Medical Oncology Dept.
🇵🇹Porto, Portugal
Hospital Beatriz Ângelo Serviço de oncologia medic
🇵🇹Loures, Portugal
Centrul de Oncologie Sf Nectarie Oncology Department
🇷🇴Craiova, Romania
S.C Oncolab S.R.L Sectia Oncologie Medicala
🇷🇴Craiova, Romania
Institutul Regional de Oncologie Iasi Clinica de Oncologie Medicala
🇷🇴Iaşi, Romania
Spitalul Clinic Judetean de Urgenta Sibiu Sectia Oncologie Medicala
🇷🇴Sibiu, Romania
S.C ONCOMED S.R.L Departament Oncologie Medicala
🇷🇴Timişoara, Romania
Arkhangelsk Clinical Oncology Dispensary chemotherapy department
🇷🇺Arkhangel'sk, Russian Federation
Universitetssjukhuset Orebro
🇸🇪Örebro, Sweden
Moscow City Oncology Hospital # 62 chemotherapy department
🇷🇺Moscow, Russian Federation
Russian Cancer Research Center n.a. NN Blokhin Clinical Pharmacology and Chemotherapy
🇷🇺Moscow, Russian Federation
University Headache Clinic Outpatient oncology clinic
🇷🇺Moscow, Russian Federation
Clinical Oncology Dispensary No.1 Chemotherapy Department
🇷🇺Krasnodar, Russian Federation
Kursk Regional Clinical Oncology Dispensary Oncology Department
🇷🇺Kursk, Russian Federation
Rostov Research Institute of Oncology Chemotherapy department
🇷🇺Rostov-on-Don, Russian Federation
Pyatigorsk Interdistrict Oncology Dispensary Chemotherapy department
🇷🇺Pyatigorsk, Russian Federation
Regional Clinical Oncology Dispensary
🇷🇺Ryazan', Russian Federation
Scientific Centre for Specialized Medical Care (oncological) Chemotherapy
🇷🇺Saint Petersburg, Russian Federation
National Medical Research Center of Oncology N.N. Petrova
🇷🇺Saint Petersburg, Russian Federation
Multidisciplinary clinic "Reaviz"
🇷🇺Samara, Russian Federation
Saint Petersburg City Oncology Clilnic
🇷🇺Saint Petersburg, Russian Federation
Oncology Dispensary No.2
🇷🇺Sochi, Russian Federation
State Research Institution of Oncology of Tomsk Chemotherapy
🇷🇺Tomsk, Russian Federation
Narodny onkologicky ustav Oddelenie klinickej onkologie
🇸🇰Bratislava, Slovakia
Hospital Germans Trias i Pujol Unidad de Investigación clínica (UIC) ICO-Oncología medica
🇪🇸Badalona, Spain
Vychodoslovensky onkologicky ustav Oddelenie klinickej onkologie
🇸🇰Košice, Slovakia
SBIH of YR "Clinical oncology hospital" chemotherapy department
🇷🇺Yaroslavl, Russian Federation
Hospital General Universitario Alicante Servicio de Oncología
🇪🇸Alicante, Spain
H. Valle de Hebrón Servicio de Oncología - (VHIR)
🇪🇸Barcelona, Spain
Omsk Clinical Oncologic Dispensary Chemotherapy
🇷🇺Omsk, Russian Federation
H. Clínico San Carlos Servicio de Oncología Médica
🇪🇸Madrid, Spain
INSTITUTO CATALAN DE ONCOLOGÍA - ICO Oncología Médica
🇪🇸Hospitalet de Llobregat, Spain
Hospital de la Santa Creu I Sant Pau Oncología Medica
🇪🇸Barcelona, Spain
Hospital Unviersitario Gregorio Marañon Servicio de Oncología Médica
🇪🇸Madrid, Spain
HOSPITAL 12 DE OCTUBRE Servicio Oncología Médica
🇪🇸Madrid, Spain
H.Virgen Del Rocio
🇪🇸Sevilla, Spain
Falu Lasarett Onkologmottagningen
🇸🇪Falun, Sweden
Hospital Universitario Miguel Servet Servicio de Oncología
🇪🇸Zaragoza, Spain
Norrlands Universitetssjukhus Cancercentrum Umea
🇸🇪Umeå, Sweden
Hospital Universitario Ramón y Cajal, Servicio de Oncologia Médica
🇪🇸Madrid, Spain
Hospital Uni. Reina Sofía - Hospital Provincial Departamento de Oncología Médica
🇪🇸Córdoba, Spain
Cherkasy Regional Oncological Dispensary Regional Clinical Oncological Centre
🇺🇦Cherkasy, Ukraine
Dnipro Regional Oncology Dispensary
🇺🇦Dnipro, Ukraine
Institute of Medical Radiology of S.P. Grygoryev of AMS UKR
🇺🇦Kharkiv, Ukraine
Municipal Institution of Kyiv Regional Council "Kyiv Regional Clinical Hospital", proctology department
🇺🇦Kyiv, Ukraine
Kyiv City Clinical Oncology Centre Chemotherapy Department #2
🇺🇦Kyiv, Ukraine
Regional Clinical Oncological Dispensary Department of Oncology
🇺🇦Zaporozhye, Ukraine
Odesa Regional Oncology Dispensary Day patient Department
🇺🇦Odesa, Ukraine
Podillia Regional Oncology Centre Chemotherapy Department
🇺🇦Vinnytsya, Ukraine
Aberdeen Royal Infirmary Oncology Department
🇬🇧Aberdeen, United Kingdom
St James's University Hospital
🇬🇧Leeds, United Kingdom
Leicester Royal Infirmary The HOPE Clinical Trials Unit
🇬🇧Leicester, United Kingdom
Christie Hospital NHS Foundation Trust GI & Endocrine
🇬🇧Manchester, United Kingdom
Imperial Healthcare NHS Trust Charing Cross Hospital
🇬🇧London, United Kingdom
Glan Clwyd Hospital North Wales Cancer Treatment Centre
🇬🇧Rhyl, United Kingdom
Klaipeda University hospital
🇱🇹Klaipėda, Lithuania
Universitätsklinikum St. Pölten Klinische Abteilung für Innere Medizin I
🇦🇹St. Poelten, Austria
North Estonia Medical Centre Foundation Oncology and Haematology clinic
🇪🇪Tallinn, Estonia
Tartu University Hospital, Hematology - Oncology clinic, Radiotherapy and oncological therapy
🇪🇪Tartu, Estonia
Spitalul Clinic "Coltea" Sectia Oncologie Medicala
🇷🇴Bucuresti, Romania
Cork University Hospital Department of Medical Oncology
🇮🇪Cork, Ireland
Bon Secours Hospital
🇮🇪Cork, Ireland
National Cancer Institute
🇱🇹Vilnius, Lithuania
Institutul Oncologic "Prof Alexandru Trestioreanu" Busuresti Sectia Oncologie Medicala I
🇷🇴Bucuresti, Romania
Przychodnia Lekarska "KOMED"
🇵🇱Konin, Poland
SPZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii Oddzial Kliniczny Onkologii i Immunoonkologii
🇵🇱Olsztyn, Poland
Bialostockie Centrum Onkologii im Marii Curie-Sklodowskiej Oddzial Onkologii Klinicznej im Dr Ewy Pileckiej z pododdzialem Chemioterapii Dziennej
🇵🇱Białystok, Poland
Opolskie Centrum Onkologii im. Tadeusza Koszarowskiego Oddzial Onkologii Klinicznej
🇵🇱Opole, Poland
Lviv Regional Oncology Center Chemotherapy department
🇺🇦Lviv, Ukraine