Antioxidant Effect of Aged Garlic Extract
Not Applicable
Completed
- Conditions
- Heavy Smoker or Non-smoker
- Registration Number
- NCT02019368
- Lead Sponsor
- Hiroshima University
- Brief Summary
This is a randomized, double-blind, placebo controlled, crossover study to determine the antioxidant effect of aged garlic extract. This study will also compare the oxidative status in heavy smokers with that in non-smokers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 60
Inclusion Criteria
- Smoking (at least 20 cigarettes per day) or non-smoking (more than 20 years)
Exclusion Criteria
- Under medication for chronic disease
- Garlic allergy
- Engaging in vigorous exercise
- Taking drugs or functional food that may possess antioxidant property
- Participation in any clinical trial within 90 days of the commencement of the trial
- Renal or hepatic dysfunction
- Heart disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Urinary 8-hydroxydeoxyguanosine (8-OHdG) Every 4 weeks (Overall 12 weeks)
- Secondary Outcome Measures
Name Time Method High sensitive CRP Every 4 weeks (Overall 12 weeks) Blood pressure Every 4 weeks (Overall 12 weeks) Indices of the second derivative of photoplethysmogram (SDPTG) Every 4 weeks (Overall 12 weeks)
Trial Locations
- Locations (1)
Hiroshima University
🇯🇵Hiroshima, Japan
Hiroshima University🇯🇵Hiroshima, Japan