Salivary, plasma metanephrines and anxiety levels in pheochromocytomas
- Conditions
- Pheochromocytoma, paraganglioma, diagnosis, metanephrines
- Registration Number
- NL-OMON20291
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 435
Inclusion Criteria
Patients (age > 18 years) with a pheochromocytoma or sympathetic paraganglioma, with elevated plasma metanephrines AND
Germline mutation carriers without elevated plasma metanephrines AND
Healthy subjects
Exclusion Criteria
The need to use medication known to influence plasma metanephrines concentration: tricyclic antidepressants, phenoxybenzamine, MAO-inhibitors, sympathomimetics, cocaine, methyldopa
Study & Design
- Study Type
- Not specified
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The diagnostic accuracy (sensitivity and specificity) of salivary levels of metanephrines
- Secondary Outcome Measures
Name Time Method 1. To evaluate the self-reported anxiety levels in patients with a PCC/sPGL, in comparison with healthy subjects and germline mutation carriers without elevated plasma metanephrines levels and to correlate the anxiety levels to the plasma metanephrines levels <br /><br>2. To determine whether position (sitting vs. supine position) influences salivary metanephrines levels. <br /><br>3. To establish a reference set for plasma and salivary metanephrines in supine position after 30 minutes of rest<br>4. To compare the ROC curves for the PCC/sPGL patients with the ROC curve of salivary and plasma metanephrines of asymptomatic germline mutation carriers. <br>