Effects of varenicline and cognitive bias modification on responses to smoking cues

Not Applicable

Completed

• Conditions: Smoking cessation; Mental and Behavioural Disorders; Mental and behavioural disorders due to use of tobacco

• Registration Number: ISRCTN65690030
• Lead Sponsor: niversity of Bristol (UK)

Brief Summary

1. 2014 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/25294104 2. 2014 results in https://www.ncbi.nlm.nih.gov/pubmed/25294104 (added 18/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2013-02-28
• Study Start: 2014-01-30
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1. Smokes > 10 manufactured cigarettes or > 15 roll up cigarettes per day
2. Smokes within one hour of waking
3. Aged between 18 and 40 years
4. Able to attend all of the study session
5. English as first language or equivalent level of fluency

Exclusion Criteria

1. Female volunteers who are pregnant or breast feeding
2. Female volunteers not using adequate contraception
3. Volunteers who do not currently have a GP
4. Current or previous substance or alcohol misuse or dependence [other than nicotine]
5. Alcohol use in excess of 35 Units/week if female or 50 Units/week if male
6. Caffeine use = 8 cups per day
7. Significant current or past psychiatric illness (Axis 1 or 2 psychiatric diagnoses) as diagnosed by a psychiatrist
8. Clinically significant abnormality including cardiology risk factors and history of arrhythmia (as assessed by self-report)
9. Ongoing use of medication (i.e. intake of any medication within 8 weeks of study, with exception of local treatment and occasional paracetamol or non-steroidal anti-inflammatory drugs, e.g., aspirin or ibuprofen)
10. Smokers actively trying to give up smoking during the study period
11. Uncorrected visual impairment (including colour-blindness)
12. Uncorrected auditory impairment
13. Condition that makes MRI scanning unsafe (e.g. metallic implants; history of metal-working)
14. Unable to tolerate scanning environment (as established during a short anatomical MRI scan on day 0)
15. Hypersensitivity to Champix

Study & Design

• Study Type: Interventional
• Study Design: Not specified