The effects of Warfarin on permacath functio
- Conditions
- Chronic kidney disease.Chronic kidney disease (CKD)
- Registration Number
- IRCT20200516047461N1
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 86
Patients who were a candidate for the second time embedding of permanent arteriovenous catheters
Informed consent to participate in the study
Age above 18 years old
History of major hemorrhages (requiring blood transfusion, retroperitoneal or intracranial hemorrhage, inducing hypovolemia, leading to more than two units decrease in hemoglobin) within the previous three months
Progressive diabetic retinopathy
Less than 12 months of life-expectancy because of systemic disease or malignancies
Poorly controlled hypertension (systolic blood pressure>200 mmHg or diastolic blood pressure>100 mmHg measured three times within two weeks)
Absolute platelet count less than 100000
International normalized ratio (INR)=1.3
Partial thrombin time (PTT)= 5 folds than the normal range
Hypersensitivity to Warfarin
Active peptic ulcer
Pregnancy or lactation
Documented aortic aneurysm
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Permcath function. Timepoint: In every hemodialysis session. Method of measurement: Catheter clotting defined as the gross visible occlusion of the catheter or the dialysis performance with less than 250 ml per minute velocity.
- Secondary Outcome Measures
Name Time Method