Effect of Prednisone onTregs and TH17
Completed
- Conditions
- Chronic Rhinosinusitis
- Registration Number
- NCT01002313
- Lead Sponsor
- University of Chicago
- Brief Summary
The primary objective of this study is to see whether systemic corticosteroids (such as Prednisone) have an effect on the peripheral blood Treg and Th17 function in patients with CRS. Patients are taking prednisone as part of their routine medical care.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Diagnosis of CRS.
- A CT scan performed in the last year depicting the severity of the disease or nasal polyps on endoscopy.
- Symptomatic at the time of entry into the study as determined by scores ≥ 1.4 on the Rhinosinusitis disability index
Exclusion Criteria
- Women who are pregnant or breastfeeding.
- Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (heart, lung, kidney, diabetes, osteoporosis, cataracts, glaucoma, neurological, oncologic, liver disease or a contraindication to taking prednisone).
- Use of any other investigational agent in the last 30 days.
- Use of clinical drugs like antihistamines, leukotriene modifiers, intranasal steroids, systemic corticosteroids in the last 15 days or immunotherapy in the last year.
- Upper respiratory infection within 14 days of study start
- Smoking within the last 2 months.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Treg cell numbers pre treatment vs post treatment
- Secondary Outcome Measures
Name Time Method Cytokine levels in cultured PBMCs pre vs post treatment
Trial Locations
- Locations (1)
The University of Chicago
🇺🇸Chicago, Illinois, United States