Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty

Completed

• Conditions: Myotoxicity
• Interventions: Other: suprainguinal fascia iliaca block

• Registration Number: NCT05505890
• Lead Sponsor: Samsun University

Brief Summary

Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. We aimed to examine plasma CPK(creatine phosphokinase) levels to see whether myotoxicity occurs or not after suprainguinal fascial plane block is applied to patients undergoing knee artroplasty surgery.

Detailed Description

During 2 months period all elligible patients undergoing knee artoplasty surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma CPK levels will be tested 3 times of all patients.(preoperative, postoperative 6th hour, postoperative 24th hour) this data will be recorded for 2 months. After this period of time data will be analysed and patients will be grouped according to the analgesic modalities used.

Study Timeline

• Study First Submitted: 2022-08-15
• Study First Submitted QC: 2022-08-17
• Study First Posted: 2022-08-18
• Study Start: 2022-12-16
• Status Verified: 2023-02
• Primary Completion: 2023-02-21
• Study Completion: 2023-02-21
• Last Update Submitted: 2023-02-21
• Last Update Posted: 2023-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• ASA 1-3
• knee artoplasty patients
• under spinal anesthesia

Exclusion Criteria

• local anesthetic allergies
• myopathies
• coagulopathies
• Obstructive sleep apne syndrome
• hearth diseases
• liver diseases
• kidney diseases
• thyroid-parathyriod dieseas
• hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
SFIPB	suprainguinal fascia iliaca block	suprainguinal fascia iliaca plane block with 50ml of %0.25 bupivacaine will be used for postoperative analgesia .

Primary Outcome Measures

Name	Time	Method
CPK levels	at postoperative 24th hour	Change from Baseline serum creatine phosphokinase at 24 hours

Secondary Outcome Measures

Name	Time	Method
Number of patients requesting rescue analgesics	up to 24 hours	Intravenous administration of meperidine 25 mg as a rescue analgesic is planned for patients who complain of severe pain despite multimodal analgesia.

Trial Locations

Locations (1)

Samsun University; 🇹🇷 Samsun, Turkey