Clinical outcomes of Descemet Stripping Only in treatment for Fuchs Endothelial Corneal Dystrophy in Thai participants
- Conditions
- 18 years and older thai participants who have Fuchs Endothelial corneal Dystrophy with clinical presentation of Photophobia or night blindness with Snellen Best Corrected Visual Acuity lower than 20/40with modified Krachmer grading of corneal dystrophy not more than gr.IVFuchs Endothelial Corneal Dystrophy , Fuchs Endothelial Dystrophy , FECD ,FED ,Descemet Stripping Only , DSO
- Registration Number
- TCTR20221019001
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 5
1.18 years and older thai participants
2.Patient who have Fuchs Endothelial corneal Dystrophy with clinical presentation of
2.1 Photophobia or visual problems in dim light .
2.2 Snellen Best Corrected Visual Acuity lower than 20/40
2.3 Modified Krachmer grading of corneal dystrophy not more than gr.IV with peripheral corneal endothelial cells greater than 1,000 cells/mm2 and corneal thickness 580-640 um
1.No light perception
2.Have chronic disease that effect on wound healing process , or uncontrolled underlying disease eg. uncontrolled Hypertension and Chronic kidney disease.
3.Immunocopromise patient.
4.Not well co-operative patient or patient who's inconvenient to follow-up
5.Patient who have other eye pathology that effects on vision eg. infectious/autoimmune keratitis or significant cataract
6.History of Rho Kinase Inhibitors drug allergy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method visual outcome at 12 months after intervention visual acuity, Endothelial cell count, Corneal Thickness
- Secondary Outcome Measures
Name Time Method complication of DSO surgery 12 months after intervention visual acuity, Endothelial cell count, Corneal Thickness