NCT01970930已完成不适用
Treatment Strategies for Myeloproliferative Neoplasms by Targeting the Tumor Suppressor P53
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- Stem cell function
研究概览
简要总结
The purpose of the study is to isolate and characterize stem cells of patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) to find out why these cells are not working the way they should be and why they seem to be sensitive to regulatory factors in the blood, such as clotting.
详细描述
Specific Aim 1: Assess the effects of RG7112 on MPN HSC/HPC p53 levels and study how it affects MPN stem cell function.
Specific Aim 2. Assess the effects of a combination of low doses of IFNα and RG7112 on MPN HSC/HPC.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •polycythemia vera or essential thrombocythemia
- •agree to give blood for study
排除标准
- 未提供
结局指标
主要结局
Stem cell function
时间窗: at one time study visit
Assess the effects of RG7112 on MPN HSC/HPC p53 levels and study how it affects MPN stem cell function.
次要结局
- CD34+ cells assays(at one time study visit)
研究者
研究点 (1)
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