Does Coenzyme Q 10 Supplementation Reduce Muscle Pain Caused by Statins? (Cholesterol Lowering Medications)

Not Applicable

Completed

• Conditions: Statin Induced Myalgia
• Interventions: Drug: Placebo control; Drug: Coenzyme Q 10

• Registration Number: NCT00716612
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

The purpose of this study is to determine whether Coenzyme Q 10 supplementation will decrease the rate of Muscle Pain in patients with previous statin related Muscle Pain.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-07-14
• Study First Submitted QC: 2008-07-15
• Study First Posted: 2008-07-16
• Study Start: 2009-01
• Primary Completion: 2012-09
• Study Completion: 2012-09
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-24
• Last Update Posted: 2013-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Patients treated for hyperlipidemia with a HMG-CoA reductase inhibitor (i.e. pravastatin, simvastatin rosuvastatin or atorvastatin) and reporting myopathic symptoms

Exclusion Criteria

• Patients with other identifiable cause of myopathy. Patients with clinical evidence of hepatic, renal, or endocrine disease; coagulopathy; or other serious medical conditions will be excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	Placebo control	PO Placebo QD
1	Coenzyme Q 10	PO Coenzyme Q 10 QD

Primary Outcome Measures

Name	Time	Method
1. The number of patients who tolerate statin at the initial dose. 2. The number of patients remaining on statin therapy. 3. Change in myalgia score.	4, 8, and 12 weeks

Trial Locations

Locations (1)

Hadassah-Hebrew University Medical Center; 🇮🇱 Jerusalem, Israel