Prognosis of Patient Evaluated for Palliative Radiotherapy

• Conditions: Cancer; Radiotherapy
• Interventions: Radiation: palliative radiotherapy

• Registration Number: NCT03797755
• Lead Sponsor: Tuen Mun Hospital

Brief Summary

Many patients with incurable cancer will receive palliative oncological treatment before their death, and radiotherapy (RT) is an important element of this. The aim of palliative RT is to alleviate symptoms and improve quality of life. An accurate and practical survival prediction model for metastatic cancer patient receiving palliative RT can assist the decision making (ranging from best supportive treatment alone for expected short survival, to dose escalation for potential better disease control).

The available survival prediction models (such Survival Prediction Score using Number of Risk Factors by Chow et al and TEACHH model) have been developed in the Western world. We therefore perform a prospective observational study 1) to assess the overall survival of patients evaluated for palliative RT at a tertiary hospital in Hong Kong, and 2) to validate the prognostic score systems in our population.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-01
• Study Start: 2019-01-01
• Study First Submitted: 2019-01-07
• Study First Submitted QC: 2019-01-07
• Last Update Submitted: 2019-01-07
• Study First Posted: 2019-01-09
• Last Update Posted: 2019-01-09
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

• All adult patients with stage IV cancer who are referred for palliative RT in Tuen Mun Hospital, including both inpatients and outpatients.

Exclusion Criteria

• Patients who have received palliative RT before (i.e. not the first course palliative RT), have non-metastatic disease, are misclassified as palliative patients.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Palliative Cancer Patients	palliative radiotherapy	Stage IV cancer patients evaluated for palliative radiotherapy.

Primary Outcome Measures

Name	Time	Method
Overall Survival	1 year	Overall Survival in the studied population

Secondary Outcome Measures

Name	Time	Method
Overall Survival by Survival Prediction Model (NRF)	3, 6, 9, 12 months	Overall Survival by Survival Prediction Score using Number of Risk Factors (NRF)
Overall Survival in Each Indication of Palliative Radiotherapy	3, 6, 9, 12 months	Indications of Palliative Radiotherapy: The indication will be as follow: spinal cord compression brain metastases tumor bleeding tumoral mass Cancer pain Superior Vena Cava Syndrome/ Airway compression
Overall Survival by Survival Prediction Model (TEACHH)	3, 6, 9, 12 months	Overall Survival by Survival Prediction Score using TEACHH Model

Trial Locations

Locations (1)

Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun; 🇭🇰 Hong Kong, Hong Kong