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临床试验/NCT03073174
NCT03073174已完成不适用

Dietary Intakes and Periodontal Outcomes After Sanative Therapy: A Follow-Up Study

Brock University1 个研究点 分布在 1 个国家目标入组 43 人开始时间: 2017年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
43
试验地点
1
主要终点
Clinical Attachment Loss (CAL) (also called Periodontal Attachment Loss)

研究概览

简要总结

A previous study, on which this study is based, found that a diet higher in fruits and vegetables, beta-carotene, vitamin C, alpha-tocopherol, and fish oils (specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) was positively associated with periodontal healing after sanative therapy (NCT02291835). The investigator's next step, in the present study, is to determine long-term benefits of sanative therapy in which patients have regular maintenance hygiene cleanings on periodontal health. Specifically, the relationship between intakes of specific foods, nutrients and supplements with clinical periodontal outcomes will be studied.

详细描述

Periodontitis is a chronic oral infection that results in the breakdown of connective tissue and alveolar bone that support the teeth. Bacteria and the body's own immune system mediate the severity of periodontitis, where teeth may become loose, fall out or have to be removed. Sanative therapy is a non-surgical process involving mechanical debridement of bacterial biofilms on roots of teeth, below the gum line. Participants in this present study previously underwent sanative therapy several years ago and have been attending the clinic for regular maintenance appointments to maintain periodontal health. While significant associations were observed with higher intakes of fruits and vegetables and specific nutrients (vitamins C and E, beta-carotene, fish oils) within a few months after sanative therapy, this study will follow-up these findings to determine if such relationships persist during a period of relatively stable periodontal health. Given new insights into a potential role of flavonoids in maintaining periodontal health, this aspect will also be studied. The overall objective is to determine if higher intakes of foods, nutrients and supplements known to have osteogenic and immunomodulatory effects are associated with improved clinical outcomes in individuals who previously underwent sanative therapy. At the regular maintenance appointment, clinical measures will be evaluated (clinical attachment loss, probing depth, bleeding on probing, plaque index). As well, the following will be evaluated: dietary intakes of macronutrients and micronutrients using the Block 2015 food frequency questionnaire; intakes of fruit, vegetables and fiber using the Block Dietary Fruit-Vegetable-Fiber Screener; nutritional supplement use and tea intake using specially developed questionnaires and salivary markers of inflammation using biochemical assays.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
19 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • previously participated in the original study (NCT02291835)

排除标准

  • under 19 years of age
  • have not participated in the previous study as this study is a direct follow-up of those participants

结局指标

主要结局

Clinical Attachment Loss (CAL) (also called Periodontal Attachment Loss)

时间窗: At maintenance appointment (1 hour)

Clinical Attachment Loss is a routine clinical measure of periodontal health (measured in mm)

次要结局

  • Probing Depth(At maintenance appointment (1 hour))
  • Plaque Index(At maintenance appointment (1 hour))
  • Bleeding on Probing(At maintenance appointment (1 hour))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Wendy E. Ward, Ph.D.

Professor and Canada Research Chair

Brock University

研究点 (1)

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