Comparison of two different doses of pre-operative nebulisation of magnesium sulphate in reducing the incidence of post operative sore throat following endotracheal intubation in patients undergoing surgery under general anaesthesia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- 1. Post operative sore throat at rest
Study Overview
Brief Summary
In this study, we will compared two different doses of pre-operative nebulisation of magnesium sulphate in reducing the incidence of post operative sore throat following endotracheal intubation in patients undergoing surgery under general anaesthesia. Incidence of post operative sore throat will be examined at rest and on swallowing at different interval of times at 0hr, 2hrs, 4hrs, 6hrs, 10hrs and 24hrs. Apart from incidence of post operative sore throat, other laryngeal complaints such as cough, hoarseness of voice, nausea and vomiting, respiratory depression and hypotension will also examine.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 20.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Age between 20 to 65 years, American society of anaesthesiologists grading 1 and 2, Mallampati scoring 1 and 2, duration of surgery more than 1 hour.
Exclusion Criteria
- •Patient refusal, allergy to drugs, head and neck surgery, American society of anaesthesiologists grade 3 and 4, patients with upper respiratory tract infection, neuromuscular diseases, patients with nasal and throat pack, age less than 20yrs and more than 65years.
Outcomes
Primary Outcomes
1. Post operative sore throat at rest
Time Frame: 0hours, 2 hours, 4hours, 6hours, 10hours, 24hours
2. Post operative sore throat on swallowing
Time Frame: 0hours, 2 hours, 4hours, 6hours, 10hours, 24hours
Secondary Outcomes
- Laryngeal complaints such as cough, hoarseness of voice, nausea and vomiting, respiratory depression and hypotension(0hours, 2 hours, 4hours, 6hours, 10hours, 24hours)
Investigators
Dr Khullar Kamnong
Sardar Patel Medical College