Pilot feasibility of 11C-MET-PET as a post-surgery baseline scan in the follow-up of high-grade gliomas for the detection of tumor recurrence
Completed
- Conditions
- braintumourGBM10029211
- Registration Number
- NL-OMON42285
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Patients with suspicion of newly diagnosed high-grade glioma who qualify for the standard treatment. Written informed consent
Exclusion Criteria
Patients with recurrent high-grade glioma or other brain tumor as a secondary diagnosis are excluded. In addition, all patients who have had previous brain surgery or radiotherapy to the brain are also excluded. Patients with only a biopsy will be excluded. Patients under the age of 18 years will not be included. General exclusion criteria for MRI are exclusion criteria for participation in this study. The general MRI exclusion criteria are: not MRI compatible ferromagnetic material, pregnancy (or presumption thereof) and claustrophobia.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The 11C-MET-PET within 48 hours postoperatively will be assessed visually and<br /><br>quantitatively and compared with the preoperative 11C-MET-PET scan. The<br /><br>11C-MET-PET data will also be checked by comparison with the results of the<br /><br>advanced MRI sequences.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>