Healthy volunteer bronchoscopy study

Not Applicable

Completed

• Conditions: Cough; Chronic cough; Signs and Symptoms

• Registration Number: ISRCTN40147207
• Lead Sponsor: niversity Hospital of South Manchester NHS Foundation Trust (UK)

Brief Summary

2012 results in https://www.ncbi.nlm.nih.gov/pubmed/22978556 (added 10/12/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2007-10-31
• Study Start: 2012-01-25
• Last Update Posted: 6 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Over 18 years of age
2. Normal lung function
3. Negative methacholine challenge (no bronchial hyper-reactivity)

Exclusion Criteria

1. Recent upper respiratory infection (<4 weeks)
2. Pregnancy / breast feeding
3. Use of inhaled or oral steroids in last three months
4. History of drug or alcohol abuse
5. Chronic respiratory, cardiovascular, gastro-intestinal, haematological, neurological or psychiatric illness or chronic ill health. This includes past histroy at any age of asthma, or current symptomatic rhinitis
6. Symptomatic gastro-oesophageal reflux or post nasal drip, or history of chronic cough
7. History of auto-immunity/diabetes mellitus
8. Current smoker
9. Ex-smoker of < 6 months or >10 pack/year history
10. History of anaphylaxis or known allergy to lignocaine/midazolam/methacholine

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence or absence of airway inflammation in healthy volunteers

Secondary Outcome Measures

Name	Time	Method
<br> 1. Lymphocyte count in healthy volunteers of different ages/sex<br> 2. Presence/absence of pepsin in lavage of healthy volunteers<br> 3. Airway wall histology in healthy volunteers<br> 4. Evidence of allergy (Immunoglobulins)<br> 5. Provision of a bank of biopsy and lavage samples from healthy volunteers for use in future research into airway wall remodelling<br>