Stress Resilience and the Brain in Burnout

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

* Age 18-55 years
* Native Dutch speakers
* Right-handed
* Normal or corrected to normal vision
* For females: Free cycling,
- Additionally, patients will need to have received a diagnosis from HSK
clinics characterized as unidentified somatoform disorder, adjustment disorder
(DSM-V) or from AMDumc with a diagnosis of burnout.

Exclusion Criteria

*General exclusion criteria for fMRI:

Metal implants or splinters, surgical clips, prostheses, artificial heart
valves, claustrophobia, electronic equipment in body (such as a pacemaker),
preg-nancy, and epilepsy. Furthermore, a potential subject who meets any of the
following criteria will be excluded from participation in this study:,

* Psychiatric:
o Current major depression, or ADHD
o Lifetime history of bipolar disorder, schizophrenia, delusional disorder,
schizoaffective disorder, schizophreniform disorder or other psychotic disorders
o Schizoid or schizotypal personality disorder
o Current alcohol- or substance dependence
o Mental retardation (IQ<70 estimated), * Somatic:
o History of trauma capitis
o Neurological disorders
o Current fungal infections

* Pre-testing use of drugs and substances:
o Use of alcohol more than 3 units/day during the week before experimental
measures
o Use of alcohol within 24 hours before measurement.
o Use of recreational drugs within the week before measurement.
o Use of any psychotropic medication, other than oxazepam, or comparable mi-nor
tranquilizer/sleep medication, during the 5 days before measurement.
o Use of oxazepam, or comparable minor tranquilizer/sleep medication, within 12
hours before measurement.
o Smoking within 3 hours before measurement.,
* For females: Pregnancy and/or use of oral contraceptive,
* For controls: A score of 3 or greater on the Burnout Assessment Inventory.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study outcome will be the stress reactivity difference in the brain<br /><br>between people with burnout and controls, and the relationship of this response<br /><br>to daily life stress reactivity and glucocorticoid dysfunction.</p><br>

Secondary Outcome Measures