The predictive value of cytokines on response to preoperative chemoradiotherapy in patients with rectal cancer.

Completed

• Conditions: rectal cancer / rectum carcinoma; 10017990; 10017991

• Registration Number: NL-OMON37973
• Lead Sponsor: Sint Antonius Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Pathohistological diagnosis of locally advanced rectal adenocarcinoma (<15 cm from the anal verge)
- Eligible for preoperative chemoradiotherapy (chemotherapy: oral capecitabine/radiotherapy: 45-50 gray in total; fractions of 1.8-2 gray) and surgery (stage 2 or 3 rectal cancer)
- Planned to undergo a venapuncture for a regular blood collection during preoperative chemoradiotherapy, before, and after surgery
- Written informed consent
- Age *18

Exclusion Criteria

- Age <18
- Serious adverse events during preoperative chemoradiotherapy
- Use of corticosteroids and/or immusuppressive drugs during or 1 month prior to the study
- Other malignancies in medical history
- Previous pelvic radiotherapy and/or chemotherapy
- Confirmed bacterial or viral infection during the study or 3 months prior to the study

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Identifying cytokines which can predict response to preoperative<br /><br>chemoradiotherapy in patients with locally advanced rectal cancer.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>