Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Thyroidectomy

Not Applicable

Recruiting

• Conditions: Thyroid Disease
• Interventions: Drug: Acetaminophen; Drug: Ibuprofen

• Registration Number: NCT05626010
• Lead Sponsor: The Catholic University of Korea

Brief Summary

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after thyroidectomy.

Detailed Description

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after thyroidectomy. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed

Study Timeline

• Status Verified: 2022-11
• Study First Submitted: 2022-11-15
• Study First Submitted QC: 2022-11-15
• Study Start: 2022-11-23
• Study First Posted: 2022-11-23
• Last Update Submitted: 2022-11-23
• Last Update Posted: 2022-11-25
• Primary Completion: 2023-10
• Study Completion: 2023-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• the patients undergoing scheduled thyroidectomy
• American Society of Anesthesiologists status 1 or 2

Exclusion Criteria

• refusal to be enrolled in the study
• emergency surgery
• hepatic or renal disease
• on chronic pain medications
• psychiatric disorders
• pregnancy, lactation
• allergy or contraindication to the study drug

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
experimental group	Ibuprofen	the combination of acetaminophen 1g and ibuprofen 300mg iv dripping
control group	Acetaminophen	acetaminophen 1g iv dripping
experimental group	Acetaminophen	the combination of acetaminophen 1g and ibuprofen 300mg iv dripping

Primary Outcome Measures

Name	Time	Method
postoperative pain	during 30 minutes after surgery	the maximal postoperative pain severity using pain scale(visual analogue scale; 0 cm=no pain; 10 cm=the worst pain)

Secondary Outcome Measures

Name	Time	Method
pain killer requirement	during 30 minutes after surgery	the incidence of the patients who require pain killer

Trial Locations

Locations (1)

Seoul St. Mary's Hospital; 🇰🇷 Seoul, Seocho-gu, Korea, Republic of