NCT00900016已完成不适用
Pharmacodynamic Study of Fibroblast Activity Protein in Patients With Localized Pancreas Cancer Undergoing Surgical Resection
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 1
- 主要终点
- Independence of tumor fibroblast activation protein (FAP) activity and Met-α2-antiplasmin expression
研究概览
简要总结
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is assessing fibroblast activity in patients with localized pancreatic cancer undergoing surgery.
详细描述
OBJECTIVES:
Primary
- To assess the degree of fibroblast activation protein (FAP) enzymatic activity at the tumor site in patients with localized pancreatic cancer.
Secondary
- To explore correlations between tumor stromal FAP enzymatic activity and stromal α_2-antiplasmin levels.
- To explore correlations between tumor FAP enzymatic activity and plasma dipeptidyl peptidase and plasma α_2-antiplasmin converting enzyme activity as potential surrogates.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Independence of tumor fibroblast activation protein (FAP) activity and Met-α2-antiplasmin expression
时间窗: Within 28 days for prior to surgery and at 3 month intervals for up to 2 years or recurrence
次要结局
- Potential plasma surrogates of plasma dipeptidyl peptidase activity and plasma antiplasmin converting enzyme(Within 28 days for prior to surgery and at 3 month intervals for up to 2 years or recurrence)
- Feasibility of exploiting the circulatory compartment to identify surrogates of tumor FAP(Within 28 days for prior to surgery and at 3 month intervals for up to 2 years or recurrence)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Biomarkers in Young Patients With NeuroblastomaNeuroblastomaNCT01169376Children's Oncology Group380
已完成
不适用
S9431: Studying Genes and Immune Response in Tumor Samples From Patients With Locally Advanced or Metastatic MelanomaMelanoma (Skin)NCT00898183SWOG Cancer Research Network91
已完成
不适用
Study of Tumor Samples From Patients With Stage III Colon Cancer Who Have Undergone Surgery and ChemotherapyColorectal CancerNCT00918827Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan2,128
已完成
不适用
SWOG 8897-A DNA Analysis in Predicting Treatment Outcome in Women With Breast Cancer in SWOG 8897Breast CancerNCT00896623SWOG Cancer Research Network1,577
已完成
2 期
Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal CancerColorectal CancerNCT00975897Medical Research Council3,240