RECOVERY Respiratory Support: Respiratory Strategies in patients with coronavirus COVID-19 – CPAP, high-flow nasal oxygen, and standard care

Not Applicable

Completed

• Conditions: Respiratory failure in patients with known or suspected COVID-19 (SARS-CoV-2 infection); Respiratory; COVID-19 (SARS-CoV-2 infection)

• Registration Number: ISRCTN16912075
• Lead Sponsor: niversity of Warwick

Brief Summary

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32727624/ protocol (added 03/08/2020) 2021 Preprint results in https://doi.org/10.1101/2021.08.02.21261379 (added 31/08/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35072713/ (added 25/01/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-04-06
• Study Completion: 2021-06-02
• Last Update Posted: 7 February 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 4002

Inclusion Criteria

Current participant inclusion criteria as of 04/05/2021:
1. Adults =18 years
2. Hospital inpatient with suspected or proven COVID-19
3. FiO2 =0.4 and SpO2 =94%
4. Plan for escalation to intubation if needed

Previous participant inclusion criteria:
1. Adults = 18 years
2. Admitted to hospital with suspected or proven COVID-19
3. On 40% oxygen (or greater) with SpO2 <94%
4. Plan for escalation to intubation if needed

Exclusion Criteria

Current participant exclusion criteria as of 04/05/2021:
1. Planned intubation and mechanical ventilation imminent within 1 hour
2. Known or clinically apparent pregnancy
3. Any absolute contraindication to CPAP or HFNO
4. Decision not to intubate due to ceiling of treatment or withdrawal of treatment anticipated
5. Equipment for both CPAP and HFNO not available

Previous participant exclusion criteria:
1. Planned intubation and mechanical ventilation imminent within 1 hour
2. Known or clinically apparent pregnancy
3. Any absolute contraindication to CPAP or HFNO
4. Decision not to intubate due to ceiling of treatment or withdrawal of care anticipated
5. Equipment for both CPAP and HFNO not available

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite outcome comprising tracheal intubation or mortality within 30 days. Mortality will be reported from hospital records up until discharge and tracked after discharge. Intubation will be obtained from hospital data.