Endogenous Modulation of Pain and Stretch Tolerance

Not Applicable

Completed

• Conditions: Pain Threshold
• Interventions: Other: Static stretch (SS); Other: Rest; Other: Exercise induced hypoalgesia (EIH); Other: Conditioned pain modulation (CPM)

• Registration Number: NCT03886883
• Lead Sponsor: University College of Northern Denmark

Brief Summary

This study investigates the role of two endogenous inhibitory mechanisms; exercise-induced hypoalgesia (EIH) and a conditioning painful stimulus (CPM) on passive joint range of motion, passive resistive torque and pain sensitivity. The study is a randomized, repeated-measures cross-over study.

Detailed Description

The increase in range of motion following stretching is related to changes in the tolerance to stretch. The mechanistic relationships behind these changes in subject sensation are however unknown but could be related to endogenous modulation of pain.

Study Timeline

• Study Start: 2017-10-01
• Primary Completion: 2017-12-30
• Study Completion: 2017-12-30
• Status Verified: 2019-03
• Study First Submitted: 2019-03-13
• Study First Submitted QC: 2019-03-20
• Study First Posted: 2019-03-22
• Last Update Submitted: 2019-03-22
• Last Update Posted: 2019-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 19

Inclusion Criteria

• Eligibility for participation included the absence of any pain or other conditions that might affect the somatosensory system.

Exclusion Criteria

• Substance abuse, History of neurological or mental disabilities, Lack of ability to comply with instructions, Delayed onset of muscle soreness.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Static stretch (SS)	Static stretch (SS)	A static stretch of the knee flexors
Rest	Rest	No intervention
Exercise-induced hypoalgesia (EIH)	Exercise induced hypoalgesia (EIH)	Exercise-induced hypoalgesia - isometric muscle contractions of the hand flexors
Conditioning painful stimulus (CPM)	Conditioned pain modulation (CPM)	Conditioned pain modulation - cold pressure test

Primary Outcome Measures

Name	Time	Method
Knee extension range of motion	Passive knee extension range of motion was measured 10 minutes after the induction of EIH, SS, Rest and CPM	Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer

Secondary Outcome Measures

Name	Time	Method
Pressure pain thresholds	Pressure pain thresholds were measured 10 minutes after the induction of EIH, SS, Rest and CPM	PRessure pain thresholds was measures using a handheld pressure algometer (Somedic AB, Hörby, Sweden.
Passive resistive torque	Passive resistive torque was measured 10 minutes after the induction of EIH, SS, Rest and CPM	Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.

Trial Locations

Locations (1)

University College of Northern Denmark; 🇩🇰 Aalborg, Denmark