The use of antibiotics in therapy resistant Lichen Sclerosus patientes

Recruiting

• Conditions: Lichen Sclerosus (geen lekenterm bekend); 10004018; 10011063

• Registration Number: NL-OMON33045
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Vulvar Lichen Sclerosus patients who do not or hardly respons to the standard therapy (ultrapotent corticosteroids)

Exclusion Criteria

History of differentiated vulvar intraepithelial neoplasia or vulvar squamous cell carcinoma

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Relief of symptoms</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Improvement of clinical picture<br /><br>- Improvement of histological abnormalities<br /><br>- Effect on quality of life<br /><br>- Demonstration of Borrelia species in the biopsies via culture and PCR<br /><br>- Demonstration of antibodies to Borrelia species in serum of patients<br /><br>- Feasibility for the patient (side effects, compliance with therapy regimen)</p><br>