Association of genetic variation of GABRA genes with blood pressure and heart rate in patients receiving propofol during general anaesthesia
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/08/056839
- Lead Sponsor
- Maulana Azad Medical College and Associated Lok Nayak Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients fulfilling criteria for American Society of Anaesthesiologists(ASA) physical status I-II
2. Age 18-60 years
3. Body mass index (BMI) 20-30kg/cm2
Exclusion Criteria
1.Hypertension and any cardiac disease
2.Pregnancy
3.Psychiatric illness or patient suffering from intellectual disability.
4.H/O allergy to propofol
5.H/O substance abuse (alcohol)
6.Neurosurgery
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the association of genotypes CC,GC,GG of GABRA2 rs11503014 gene with post induction hypotension with propofol in patients undergoing general anaesthesia.Timepoint: 0 minute , every minute thereafter till 8 minutes, 10 minutes, 15 minutes
- Secondary Outcome Measures
Name Time Method 1.To study the relationship between genotypes AA, AG, GG of GABRA1 rs2279020 gene & genotypes TT, TC, CC of GABRA1 rs1157122 with hypotension after induction of anaesthesia with propofol. <br/ ><br>2.Total requirement of fluid for correcting hypotension induced by propofol during anaesthesia. <br/ ><br>3.To determine ephedrine requirement for hypotension not responding to fluid boluses. <br/ ><br>Timepoint: 0 minute , every minute thereafter till 8 minutes, 10 minutes, 15 minutes