Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Not Applicable

• Conditions: Apical Periodontitis
• Interventions: Other: Method

• Registration Number: NCT04158232
• Lead Sponsor: Minia University

Brief Summary

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-10-31
• Status Verified: 2019-11
• Study Start: 2019-11-02
• Study First Submitted QC: 2019-11-06
• Last Update Submitted: 2019-11-06
• Study First Posted: 2019-11-08
• Last Update Posted: 2019-11-08
• Primary Completion: 2020-09-02
• Study Completion: 2020-11-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients with mature teeth.
• Patients with periapical periodontitis.
• Maxillary anterior teeth only will be involved.
• Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
• Patients who will agree to the consent and will commit to follow up period.

Exclusion Criteria

• Patients with immature roots.
• Patients with any systemic disease that may affect normal healing.
• Patients with swelling.
• Pregnant females.
• Patients who could/would not participate in a 1 year follow up.
• Patients with fistula.
• Patients with old age.
• Teeth with periodontal involvement.
• Teeth with vertical root fractures.
• Unrestorable teeth.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
platelet rich fibrin for pulp regeneration	Method	pulp regeneration for mature teeth using platelet rich fibrin (PRF)
Blood clotting protocol for pulp regeneration	Method	pulp regeneration for mature teeth using blood clotting protocol

Primary Outcome Measures

Name	Time	Method
clinical success	9 months	pulp vitality testing using electric pulp tester which detect response of pulp to electric current
radiographic success	9 months	healing of apical periodontitis by detecting change in apical radiolucency and absences of apical bone resorption