Fructose Rich Diet and Endothelial Function

Not Applicable

Completed

• Conditions: Metabolic Disease; Aerobic Exercise; Fructose Rich Diet; Fructose Metabolism Disorder

• Registration Number: NCT03939130
• Lead Sponsor: Federal University of Rio Grande do Sul

Brief Summary

Cardiometabolic diseases have been associated with high consumption of sweetened beverages. These products are responsible for the largest portion of the total consumption of fructose in the diet and it is suggested that excessive intake of this monosaccharide may contribute to the development of risk factors for these diseases due to differences in metabolism relative to glucose. However, there is a lack of data in the literature demonstrating the deleterious effects of excessive fructose consumption on vasodilation and whether aerobic training may be able to prevent or mitigate these damages in humans. Therefore, the aim of the study will be to verify the effect of 4 weeks of high fructose diet associated with aerobic training on uric acid levels and its influence on markers related to oxidative stress and vasodilatation. Twenty-one sedentary men and women, aged between 19 and 35 years, will be submitted to 4 weeks of intervention. In a randomized way, subjects will be divided into 3 groups: high fructose diet, high glucose diet and high fructose diet and exercise. Blood samples will be taken before, in the middle and after the intervention to verify the concentrations of uric acid, superoxide dismutase enzyme, thiobarbituric acid, nitrite / nitrate, lipid profile, glucose, insulin, C-reactive protein and endothelin-1. In addition, flow-mediated dilatation, insulin resistance index, pancreatic beta cell functional capacity index, oral glucose tolerance test, 24-hour blood pressure, heart rate variability and body composition will be analyzed. The comparisons will be performed through the Generalized Estimates of Equations, adopting the factors group and time. The Bonferroni post-hoc will be used to identify differences. The accepted level of significance will be 5%.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-01
• Primary Completion: 2018-12-23
• Study Completion: 2018-12-23
• Study First Submitted: 2019-04-29
• Status Verified: 2019-05
• Study First Submitted QC: 2019-05-02
• Last Update Submitted: 2019-05-02
• Study First Posted: 2019-05-06
• Last Update Posted: 2019-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Men and women;
• Not engaged in regular exercises;
• Aged between 19 and 35 years;
• Body mass index (BMI) of less than 30kg / m².

Exclusion Criteria

• Individuals with BMI below 18kg / m² and greater than 30kg / m²;
• Smokers;
• Dyslipidemic;
• Diabetic;
• Hypertensive;
• Alcohol use;
• Appetite suppressants use;
• Medications use;
• Supplements use;
• Chronic disease that impedes the performance of physical exercise.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Flow Mediated Dilatation	4 weeks
Concentration of Nitrite / Nitrate	4 weeks
Concentration of Uric Acid	4 weeks

Secondary Outcome Measures

Name	Time	Method
Concentration of Substances Reactive to Thiobarbituric Acid	4 weeks	Oxidative stress outcome
Concentration of Endothelin-1	4 weeks
Concentration of Insulin	4 weeks
Concentration of Superoxide Dismutase Enzyme	4 weeks
Insulin Sensitivity	4 weeks	Oral glucose tolerance test
Concentration of Triglycerides	4 weeks
Concentration of Low-Density Lipoprotein	4 weeks
HOMA-B	4 weeks
24-hour Blood Pressure	4 weeks
Concentration of Glucose	4 weeks
HOMA-IR	4 weeks
Concentration of C-Reactive Protein	4 weeks
Heart Rate Variability	4 weeks
Body Fat	4 weeks
Concentration of Total Cholesterol	4 weeks
Concentration of High-Density Lipoprotein	4 weeks

Trial Locations

Locations (1)

Universidade Federal do Rio Grande do Sul; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil